Genes Required for Survival in Microgravity Revealed by Genome-Wide Yeast Deletion Collections Cultured during Spaceflight

Table 3

Concordance between drug effects and spaceflight effects on yeast genome responses identified with the homozygous deletion series (+NaCl).

Drug (concordance)	Biological function
5-Fluorouridine (0.42); 5-Fluorouracil (0.36); Carmofur (0.34); 5-Fluorocytosine (0.35)	Pyrimidine analogs that inhibit thymidylate synthase and are metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA
8-Methoxypsoralen (0.32)	DNA-damaging agent
Diallyl disulfide (0.4)	Increased glutathione-S-transferase changes redox state by binding electrophilic toxins