|
Model | Outcome | Reference no. |
|
High-fat diet- (HFD-) fed mice versus controls subjected to bile duct ligation (BDL) or hepatotoxin CCl4 | HFD mice subjected to BDL had an increase of Bacteroidetes, Firmicutes, and Proteobacteria | [20] |
|
Methionine-choline-deficient diet-fed mice versus HFD-fed mice | Inflammasome deficiency-associated changes in gut microbiota were associated with exacerbated hepatic steatosis and inflammation | [21] |
|
HFD-fed germ-free mice colonized with intestinal microbiota from a responder donor (developed hyperglycaemia and higher proinflammatory cytokines) or a nonresponder | Responder-receiver developed hepatic macrovesicular steatosis and harbour distinct gut microbiota | [22] |
|
Low-fat diet based on palm oil (LFD-PO) fed mice versus HFD based on palm oil (HFD-PO) versus olive oil (HFD-OO) versus safflower oil (HFD-SO) | The HFD-PO diet induced higher liver triglyceride content, reduced microbial diversity, and increased the Firmicutes-to-Bacteroidetes ratio | [23] |
|
HFD-fed mice versus low-fat diet-fed mice | Quantitative variation in dietary choline induced an inverse quantitative variation in liver fat content; conversion of choline into methylamines by microbiota in mice on a HFD caused NAFLD | [24] |
|
HFD-fed mice versus HFD supplemented with chitin-glucan (CG) versus controls | CG treatment significantly decreased hepatic triglyceride accumulation, which was negatively correlated with specific bacteria of clostridial cluster XIVa, that is, Roseburia spp. | [25] |
|
High-fructose diet-fed mice supplemented with Lactobacillus rhamnosus GG (LGC) versus controls | Supplementation with LGC reduced liver fat accumulation and increased intestinal Firmicutes and Bacteroidetes | [26] |
|
Methionine-choline-deficient-diet-fed mice (MCD) versus MCD-fed mice supplemented with Lactobacillus casei strain Shirota (LcS) versus controls | Bifidobacterium and Lactobacillus were markedly reduced by the MCD diet. Administration of LcS increased the L. casei subgroup and other lactic acid bacteria | [27] |
|
HFD-fed rats supplementation with an herbal formula (HF) versus no supplementation versus controls | Supplementation of HF decreased hepatic steatosis; Escherichia/Shigella were enriched in HFD-fed rats but decreased to control levels after HF treatment | [28] |
|
HFD-fed mice supplemented with Bacteroides uniformis CECT7771 versus controls | Supplementation with Bacteroides uniformis reduced NAFLD in HFD-mice; HFD resulted in marked changes in gut microbiota, partially restored by the intervention | [29] |
|
N-3 PUFA-depleted diet-fed mice supplemented with fructooligosaccharides (FOS) versus controls | Supplementation with FOS reverses NAFLD induced by n-3 PUFA-depleted diet; FOS-treated mice exhibited higher caecal Bifidobacterium spp. and lower Roseburia spp. content and reduced hepatic triglyceride accumulation | [30] |
|
Fructose-fed mice versus controls treated or not with antibiotics | Hepatic fat accumulation was associated with a significant induction of TLR 1–4 and 6–8. The effects of fructose were attenuated in antibiotic-treated mice. No systematic alterations of microbiota were found | [31] |
|