Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 984528, 8 pages
http://dx.doi.org/10.1155/2015/984528
Clinical Study

Long-Term Clinical Outcome after Treatment for High-Grade Cervical Lesions: A Retrospective Monoinstitutional Cohort Study

1Immunology and Molecular Oncology Unit, Veneto Institute of Oncology-(IOV-) IRCCS, Via Gattamelata 64, 35128 Padua, Italy
2Department of Woman and Child Health, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35128 Padua, Italy
3Department of Pathology, Azienda Ospedaliera di Padova, Via Gabelli, 35121 Padua, Italy
4Veneto Tumour Registry, Passaggio Gaudenzio 1, 35131 Padua, Italy
5Department of Surgery, Oncology and Gastroenterology, University of Padua, 35128 Padua, Italy

Received 8 August 2014; Revised 5 December 2014; Accepted 10 March 2015

Academic Editor: Walter Prendiville

Copyright © 2015 Annarosa Del Mistro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. R. McCredie, K. J. Sharples, C. Paul et al., “Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study,” The Lancet Oncology, vol. 9, no. 5, pp. 425–434, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Kyrgiou, G. Valasoulis, C. Founta et al., “Clinical management of HPV-related disease of the lower genital tract,” Annals of the New York Academy of Sciences, vol. 1205, pp. 57–68, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. P. E. Castle, M. Schiffman, C. M. Wheeler, and D. Solomon, “Evidence for frequent regression of cervical intraepithelial neoplasia-grade 2,” Obstetrics & Gynecology, vol. 113, no. 1, pp. 18–25, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Kocken, T. J. M. Helmerhorst, J. Berkhof et al., “Risk of recurrent high-grade cervical intraepithelial neoplasia after successful treatment: A long-term multi-cohort study,” The Lancet Oncology, vol. 12, no. 5, pp. 441–450, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. W. P. Soutter, A. de Barros Lopes, A. Fletcher et al., “Invasive cervical cancer after conservative therapy for cervical intraepithelial neoplasia,” The Lancet, vol. 349, no. 9057, pp. 978–980, 1997. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Kalliala, A. Anttila, E. Pukkala, and P. Nieminen, “Risk of cervical and other cancers after treatment of cervical intraepithelial neoplasia: retrospective cohort study,” British Medical Journal, vol. 331, no. 7526, pp. 1183–1185, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Strander, J. Hällgren, and P. Sparén, “Effect of ageing on cervical or vaginal cancer in Swedish women previously treated for cervical intraepithelial neoplasia grade 3: population based cohort study of long term incidence and mortality,” British Medical Journal, vol. 348, article f7361, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. A. R. Kreimer, R. S. Guido, D. Solomon et al., “Human papillomavirus testing following loop electrosurgical excision procedure identifies women at risk for posttreatment cervical intraepithelial neoplasia grade 2 or 3 disease,” Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 5, pp. 908–914, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Koliopoulos, M. Arbyn, P. Martin-Hirsch, M. Kyrgiou, W. Prendiville, and E. Paraskevaidis, “Diagnostic accuracy of human papillomavirus testing in primary cervical screening: a systematic review and meta-analysis of non-randomized studies,” Gynecologic Oncology, vol. 104, no. 1, pp. 232–246, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. H. C. Kitchener, P. G. Walker, L. Nelson et al., “HPV testing as an adjunct to cytology in the follow up of women treated for cervical intraepithelial neoplasia,” British Journal of Obstetrics and Gynaecology, vol. 115, no. 8, pp. 1001–1007, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Kocken, M. H. Uijterwaal, A. L. M. de Vries et al., “High-risk human papillomavirus testing versus cytology in predicting post-treatment disease in women treated for high-grade cervical disease: a systematic review and meta-analysis,” Gynecologic Oncology, vol. 125, no. 2, pp. 500–507, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Arbyn, G. Ronco, A. Anttila et al., “Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer,” Vaccine, vol. 30, supplement 5, pp. F88–F99, 2012. View at Google Scholar
  13. M. Gök, V. M. H. Coupé, J. Berkhof et al., “HPV16 and increased risk of recurrence after treatment for CIN,” Gynecologic Oncology, vol. 104, no. 2, pp. 273–275, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Heymans, I. H. Benoy, W. Poppe, and C. E. Depuydt, “Type-specific HPV geno-typing improves detection of recurrent high-grade cervical neoplasia after conisation,” International Journal of Cancer, vol. 129, no. 4, pp. 903–909, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Walker, S. Dexeus, G. de Palo et al., “International terminology of colposcopy: an updated report from the international federation for cervical pathology and colposcopy,” Obstetrics and Gynecology, vol. 101, no. 1, pp. 175–177, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Minucci, A. Cinel, and E. Insacco, “Diathermic loop treatment for CIN and HPV lesions. A follow-up of 130 cases,” European Journal of Gynaecological Oncology, vol. 12, no. 5, pp. 385–393, 1991. View at Google Scholar · View at Scopus
  17. P. Leguevaque, S. Motton, A. Decharme, M. Soulé-Tholy, G. Escourrou, and J. Hoff, “Predictors of recurrence in high-grade cervical lesions and a plan of management,” European Journal of Surgical Oncology, vol. 36, no. 11, pp. 1073–1079, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Del Mistro, H. Frayle-Salamanca, R. Trevisan et al., “Triage of women with atypical squamous cells of undetermined significance (ASC-US): results of an Italian multicentric study,” Gynecologic Oncology, vol. 117, no. 1, pp. 77–81, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. V. Bouvard, R. Baan, K. Straif et al., “A review of human carcinogens—part B: biological agents,” The Lancet Oncology, vol. 10, no. 4, pp. 321–322, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Melnikow, C. McGahan, G. F. Sawaya, T. Ehlen, and A. Coldman, “Cervical intraepithelial neoplasia outcomes after treatment: long-term follow-up from the british columbia cohort study,” Journal of the National Cancer Institute, vol. 101, no. 10, pp. 721–728, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Rebolj, T. Helmerhorst, D. Habbema et al., “Risk of cervical cancer after completed post-treatment follow-up of cervical intraepithelial neoplasia: population based cohort study,” British Medical Journal, vol. 345, no. 7882, Article ID e6855, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. M. L. Tornesello, L. Buonaguro, P. Giorgi-Rossi, and F. M. Buonaguro, “Viral and cellular biomarkers in the diagnosis of cervical intraepithelial neoplasia and cancer,” BioMed Research International, vol. 2013, Article ID 519619, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Origoni, M. Parma, G. Dell'Antonio et al., “Prognostic significance of immunohistochemical phenotypes in patients treated for high-grade cervical intraepithelial neoplasia,” BioMed Research International, vol. 2013, Article ID 831907, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Papakonstantinou, Ma. Kyrgiou, D. Lyons, W. P. Soutter, and S. Ghaem-Maghami, “Management of stage Ia1 squamous cervical cancer and the importance of excision margins: a retrospective study of long-term outcome after 25 years of follow-up,” The American Journal of Obstetrics and Gynecology, vol. 211, no. 6, pp. 625.e1–625.e6, 2014. View at Publisher · View at Google Scholar
  25. K. U. Petry, A. Luyten, and S. Scherbring, “Accuracy of colposcopy management to detect CIN3 and invasive cancer in women with abnormal screening tests: results from a primary HPV screening project from 2006 to 2011 in Wolfsburg, Germany,” Gynecologic Oncology, vol. 128, no. 2, pp. 282–287, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Nam, S. Chung, J. Kwak et al., “Random biopsy after colposcopy-directed biopsy improves the diagnosis of cervical intraepithelial neoplasia grade 2 or worse,” Journal of Lower Genital Tract Disease, vol. 14, no. 4, pp. 346–351, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Underwood, M. Arbyn, W. Parry-Smith et al., “Accuracy of colposcopy-directed punch biopsies: a systematic review and meta-analysis,” British Journal of Obstetrics and Gynaecology, vol. 119, no. 11, pp. 1293–1301, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. S. C. Leeson, T. Alibegashvili, M. Arbyn et al., “The future role for colposcopy in Europe,” Journal of Lower Genital Tract Disease, vol. 18, no. 1, pp. 70–78, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. S. K. Kjær, K. Frederiksen, C. Munk, and T. Iftner, “Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence,” Journal of the National Cancer Institute, vol. 102, no. 19, pp. 1478–1488, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Wentzensen, J. Walker, M. Schiffman et al., “Heterogeneity of high-grade cervical intraepithelial neoplasia related to HPV16: implications for natural history and management,” International Journal of Cancer, vol. 132, no. 1, pp. 148–154, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Luhn, J. Walker, M. Schiffman et al., “The role of co-factors in the progression from human papillomavirus infection to cervical cancer,” Gynecologic Oncology, vol. 128, no. 2, pp. 265–270, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Confortini, G. Ronco, F. M. Carozzi, A. Iossa, and P. G. Rossi, Eds., Utilizzo del test HPV-hr nel triage delle ASC-US, delle L-SIL in donne con più di 35 anni, nel follow-up delle donne con citologia ASC-US+ dopo un approfondimento di secondo livello negativo per CIN2+ e nel follow-up dopo trattamento delle lesioni CIN2-3: aggiornamento 2012, Gruppo trasversale GISCi sull’HPV, 2012, http://www.gisci.it/documenti/documenti_gisci/Aggiornamento_documento_GISCI_2012_HPV-hr.pdf.
  33. NHS Cancer Screening Programmes, Colposcopy and Programme Management. Guidelines for the NHS Cervical Screening Programme, NHSCSP, 2nd edition, 2010.
  34. V. Thompson and R. Marin, “Is Colposcopy necessary at twelve months after large loop excision of the transformation zone? A clinical audit,” Australian and New Zealand Journal of Obstetrics and Gynaecology, vol. 53, no. 6, pp. 571–573, 2013. View at Publisher · View at Google Scholar · View at Scopus