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BioMed Research International
Volume 2015, Article ID 985814, 6 pages
http://dx.doi.org/10.1155/2015/985814
Review Article

The Role of Microvesicles Derived from Mesenchymal Stem Cells in Lung Diseases

1Department of Respiratory Medicine, Chinese People’s Liberation Army General Hospital, Chinese People’s Liberation Army Medical College, Beijing, China
2Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing, China
3Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing, China

Received 11 July 2014; Accepted 23 August 2014

Academic Editor: Aaron W. James

Copyright © 2015 Jie Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. Friedenstein, K. V. Petrakova, A. I. Kurolesova, and G. P. Frolova, “Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues,” Transplantation, vol. 6, no. 2, pp. 230–247, 1968. View at Publisher · View at Google Scholar · View at Scopus
  2. Y.-Y. Wang, X.-Z. Li, and L.-B. Wang, “Therapeutic implications of mesenchymal stem cells in acute lung injury/acute respiratory distress syndrome,” Stem Cell Research and Therapy, vol. 4, no. 3, article 45, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Biancone, S. Bruno, M. C. Deregibus, C. Tetta, and G. Camussi, “Therapeutic potential of mesenchymal stem cell-derived microvesicles,” Nephrology Dialysis Transplantation, vol. 27, no. 8, pp. 3037–3042, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. S. R. Baglio, D. M. Pegtel, and N. Baldini, “Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy,” Frontiers in Physiology, vol. 3, no. 359, pp. 1–10, 2012. View at Publisher · View at Google Scholar
  5. T. van Haaften, R. Byrne, S. Bonnet et al., “Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats,” American Journal of Respiratory and Critical Care Medicine, vol. 180, no. 11, pp. 1131–1142, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. K.-Y. Yang, H.-C. Shih, C.-K. How et al., “IV delivery of induced pluripotent stem cells attenuates endotoxin-induced acute lung injury in mice,” Chest, vol. 140, no. 5, pp. 1243–1253, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. J. W. Lee, X. Fang, A. Krasnodembskaya, J. P. Howard, and M. A. Matthay, “Concise review: mesenchymal stem cells for acute lung injury: role of paracrine soluble factors,” Stem Cells, vol. 29, no. 6, pp. 913–919, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. J. W. Lee, X. Fang, N. Gupta, V. Serikov, and M. A. Matthay, “Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 38, pp. 16357–16362, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Sun, Z.-B. Han, W. Liao et al., “Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute lung injury by expanding CD4+CD25+ forkhead Boxp3 (FOXP3)+ regulatory T cells and balancing anti- and pro-inflammatory factors,” Cellular Physiology and Biochemistry, vol. 27, no. 5, pp. 587–596, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Jun, C. Garat, J. West et al., “The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation,” Stem Cells, vol. 29, no. 4, pp. 725–735, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Ionescu, R. N. Byrne, T. van Haaften et al., “Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action,” American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 303, no. 11, pp. L967–L977, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. Z.-H. Qin, J.-F. Xu, J.-M. Qu et al., “Intrapleural delivery of MSCs attenuates acute lung injury by paracrine/endocrine mechanism,” Journal of Cellular and Molecular Medicine, vol. 16, no. 11, pp. 2745–2753, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Chen, C. Li, X. Gao et al., “Keratinocyte growth factor gene delivery via mesenchymal stem cells protects against lipopolysaccharide-induced acute lung injury in mice,” PLoS ONE, vol. 8, no. 12, Article ID e83303, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Wang, Y.-F. Yang, L. Zhao et al., “Hepatocyte growth factor gene-modified mesenchymal stem cells reduce radiation-induced lung injury,” Human Gene Therapy, vol. 24, no. 3, pp. 343–353, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. G. F. Curley, M. Hayes, B. Ansari et al., “Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat,” Thorax, vol. 67, no. 6, pp. 496–501, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. S. H. J. Mei, S. D. McCarter, Y. Deng, C. H. Parker, W. C. Liles, and D. J. Stewart, “Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin,” PLoS Medicine, vol. 4, no. 9, pp. 1525–1537, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Krasnodembskaya, Y. Song, X. Fang et al., “Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37,” Stem Cells, vol. 28, no. 12, pp. 2229–2238, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. J. W. Lee, N. Gupta, V. Serikov, and M. A. Matthay, “Potential application of mesenchymal stem cells in acute lung injury,” Expert Opinion on Biological Therapy, vol. 9, no. 10, pp. 1259–1270, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Aggarwal and M. F. Pittenger, “Human mesenchymal stem cells modulate allogeneic immune cell responses,” Blood, vol. 105, no. 4, pp. 1815–1822, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. J. L. Chan, K. C. Tang, A. P. Patel et al., “Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-γ,” Blood, vol. 107, no. 12, pp. 4817–4824, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Stagg, S. Pommey, N. Eliopoulos, and J. Galipeau, “Interferon-γ-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell,” Blood, vol. 107, no. 6, pp. 2570–2577, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Sun, Z.-B. Han, W. Liao et al., “Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute lung injury by expanding CD4+CD25+ forkhead Boxp3 (FOXP3) + regulatory T cells and balancing anti- and pro-inflammatory factors,” Cellular Physiology and Biochemistry, vol. 27, no. 5, pp. 587–596, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Camussi, M. C. Deregibus, S. Bruno, V. Cantaluppi, and L. Biancone, “Exosomes/microvesicles as a mechanism of cell-to-cell communication,” Kidney International, vol. 78, no. 9, pp. 838–848, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. B. György, T. G. Szabó, M. Pásztói et al., “Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles,” Cellular and Molecular Life Sciences, vol. 68, no. 16, pp. 2667–2688, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. G. Camussi, M. C. Deregibus, and V. Cantaluppi, “Role of stem-cell-derived microvesicles in the paracrine action of stem cells,” Biochemical Society Transactions, vol. 41, no. 1, pp. 283–287, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Bruno and G. Camussi, “Role of mesenchymal stem cell-derived microvesicles in tissue repair,” Pediatric Nephrology, vol. 28, no. 12, pp. 2249–2254, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Janowska-Wieczorek, M. Majka, J. Kijowski et al., “Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment,” Blood, vol. 98, no. 10, pp. 3143–3149, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. O. P. Barry, D. Praticò, R. C. Savani, and G. A. FitzGerald, “Modulation of monocyte-endothelial cell interactions by platelet microparticles,” Journal of Clinical Investigation, vol. 102, no. 1, pp. 136–144, 1998. View at Publisher · View at Google Scholar · View at Scopus
  29. S. F. Mause and C. Weber, “Microparticles: protagonists of a novel communication network for intercellular information exchange,” Circulation Research, vol. 107, no. 9, pp. 1047–1057, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Taraboletti, S. D'Ascenzo, I. Giusti et al., “Bioavailability of VEGF in tumor-shed vesicles depends on vesicle burst induced by acidic pH 1,” Neoplasia, vol. 8, no. 2, pp. 96–103, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. G. Taraboletti, S. D'Ascenzo, P. Borsotti, R. Giavazzi, A. Pavan, and V. Dolo, “Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells,” The American Journal of Pathology, vol. 160, no. 2, pp. 673–680, 2002. View at Google Scholar · View at Scopus
  32. S. S. Sidhu, A. T. Mengistab, A. N. Tauscher, J. LaVail, and C. Basbaum, “The microvesicle as a vehicle for EMMPRin in tumor-stromal interactions,” Oncogene, vol. 23, no. 4, pp. 956–963, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Sarkar, S. Mitra, S. Mehta, R. Raices, and M. D. Wewers, “Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1,” PLoS ONE, vol. 4, no. 9, Article ID e7140, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Ratajczak, K. Miekus, M. Kucia et al., “Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery,” Leukemia, vol. 20, no. 5, pp. 847–856, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. M. C. Deregibus, V. Cantaluppi, R. Calogero et al., “Endothelial progenitor cell—derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA,” Blood, vol. 110, no. 7, pp. 2440–2448, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Tomasoni, L. Longaretti, C. Rota et al., “Transfer of growth factor receptor mRNA via exosomes unravels the regenerative effect of mesenchymal stem cells,” Stem Cells and Development, vol. 22, no. 5, pp. 772–780, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. F. Collino, M. C. Deregibus, S. Bruno et al., “Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs,” PLoS ONE, vol. 5, no. 7, Article ID e11803, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. M. S. Dooner, J. M. Aliotta, J. Pimentel et al., “Conversion potential of marrow cells into lung cells fluctuates with cytokine-induced cell cycle,” Stem Cells and Development, vol. 17, no. 2, pp. 207–219, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. C. Lee, S. A. Mitsialis, M. Aslam et al., “Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension,” Circulation, vol. 126, no. 22, pp. 2601–2611, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. Y. G. Zhu, X. M. Feng, J. Abbott et al., “Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice,” Stem Cells, vol. 32, no. 1, pp. 116–125, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Bruno, C. Grange, M. C. Deregibus et al., “Mesenchymal stem cell-derived microvesicles protect against acute tubular injury,” Journal of the American Society of Nephrology, vol. 20, no. 5, pp. 1053–1067, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Bruno, C. Grange, F. Collino et al., “Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury,” PLoS ONE, vol. 7, no. 3, Article ID e33115, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. H. Xin, Y. Li, Z. Liu et al., “MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles,” Stem Cells, vol. 31, no. 12, pp. 2737–2746, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. R. C. Lai, F. Arslan, M. M. Lee et al., “Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury,” Stem Cell Research, vol. 4, no. 3, pp. 214–222, 2010. View at Publisher · View at Google Scholar · View at Scopus