Rapamycin Protects from Type-I Peritoneal Membrane Failure Inhibiting the Angiogenesis, Lymphangiogenesis, and Endo-MT

Figure 4

Rapamycin decreases VEGF and TNF-α levels in the peritoneal cavity. (a) Analysis of VEGF and (b) TNF-alpha in the drained volumes shows a strong increase of these factors in PD fluid-instilled animals, and administration of Rapamycin significantly reduces their production. The one-way ANOVA test resulted in a significance of and , respectively. (c) Total numbers of cells in the drained effluent do not show statistical differences between groups. Box plots graphics represent 25th and 75th percentiles and median, minimum, and maximum values. Numbers above boxes depict means ± SE. Symbols represent the statistic differences between groups.

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(b)

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