Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 1038034, 7 pages
Clinical Study

The Effect of Esmolol on Tissue Perfusion and Clinical Prognosis of Patients with Severe Sepsis: A Prospective Cohort Study

1Department of Critical Care Medicine, Fujian Provincial Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China
2Department of Research, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China
3Department of Critical Care Medicine, Chinese Medicine Hospital, Fuzhou, Fujian 350001, China

Received 17 April 2016; Revised 20 June 2016; Accepted 12 July 2016

Academic Editor: Evangelos J. Giamarellos-Bourboulis

Copyright © 2016 Xiuling Shang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. This study was aimed at investigating the effect of esmolol on tissue perfusion and the clinical prognosis of patients with severe sepsis. Materials and Methods. One hundred fifty-one patients with severe sepsis were selected and divided into the esmolol group () or the control group (), who received conventional antiseptic shock treatment. The esmolol group received a continuous infusion of esmolol via a central venous catheter, and their heart rate (HR) was maintained at 70–100 bpm over 72 hours. Results. The HR of all patients reached the target level within 72 hours of treatment for both groups. The effect of esmolol on PvaCO2 was only significant at 48 hours (). ScvO2 increased in the esmolol group and decreased in the control group (). Lac showed a linear downward trend over the treatment time, but the reduction was more significant in the control group at 48 hours () between the two groups. Kaplan-Meier analysis showed a significantly shorter duration of mechanical ventilation in the esmolol group than in the control group (). Conclusions. Esmolol reduced the duration of mechanical ventilation in patients with severe sepsis, with no significant effect on circulatory function or tissue perfusion.