Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016 (2016), Article ID 1038034, 7 pages
http://dx.doi.org/10.1155/2016/1038034
Clinical Study

The Effect of Esmolol on Tissue Perfusion and Clinical Prognosis of Patients with Severe Sepsis: A Prospective Cohort Study

1Department of Critical Care Medicine, Fujian Provincial Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China
2Department of Research, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China
3Department of Critical Care Medicine, Chinese Medicine Hospital, Fuzhou, Fujian 350001, China

Received 17 April 2016; Revised 20 June 2016; Accepted 12 July 2016

Academic Editor: Evangelos J. Giamarellos-Bourboulis

Copyright © 2016 Xiuling Shang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. P. Dellinger, M. M. Levy, A. Rhodes et al., “Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012,” Intensive Care Medicine, vol. 39, no. 2, pp. 165–228, 2013. View at Publisher · View at Google Scholar
  2. G. Wernovsky, D. Wypij, R. A. Jonas et al., “Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants: a comparison of low-flow cardiopulmonary bypass and circulatory arrest,” Circulation, vol. 92, no. 8, pp. 2226–2235, 1995. View at Publisher · View at Google Scholar · View at Scopus
  3. J. L. Berk, J. F. Hagen, W. H. Beyer, M. J. Gerber, and G. R. Dochat, “The treatment of endotoxin shock by beta adrenergic blockade,” Annals of Surgery, vol. 169, no. 1, pp. 74–81, 1969. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Suzuki, H. Morisaki, R. Serita et al., “Infusion of the β-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rat,” Critical Care Medicine, vol. 33, no. 10, pp. 2294–2301, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. O. Joulin, S. Marechaux, S. Hassoun, D. Montaigne, S. Lancel, and R. Neviere, “Cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in LPS-treated rats,” Critical Care, vol. 13, no. 1, article R14, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Werdan, A. Oelke, S. Hettwer et al., “Septic cardiomyopathy: hemodynamic quantification, occurrence, and prognostic implications,” Clinical Research in Cardiology, vol. 100, no. 8, pp. 661–668, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. A. R. Lyon, P. S. C. Rees, S. Prasad, P. A. Poole-Wilson, and S. E. Harding, “Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning,” Nature Clinical Practice Cardiovascular Medicine, vol. 5, no. 1, pp. 22–29, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Aboab, V. Sebille, M. Jourdain et al., “Effects of esmolol on systemic and pulmonary hemodynamics and on oxygenation in pigs with hypodynamic endotoxin shock,” Intensive Care Medicine, vol. 37, no. 8, pp. 1344–1351, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Silasi-Mansat, H. Zhu, N. I. Popescu et al., “Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis,” Blood, vol. 116, no. 6, pp. 1002–1010, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. C. A. Schmittinger, M. W. Dünser, M. Haller et al., “Combined milrinone and enteral metoprolol therapy in patients with septic myocardial depression,” Critical Care, vol. 12, no. 4, article R99, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Christensen, M. B. Johansen, E. Tønnesen et al., “Preadmission beta-blocker use and 30-day mortality among patients in intensive care: a cohort study,” Critical Care, vol. 15, no. 2, article R87, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Morelli, C. Ertmer, M. Westphal et al., “Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial,” Journal of the American Medical Association, vol. 310, no. 16, pp. 1683–1691, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Morelli, A. Donati, C. Ertmer et al., “Microvascular effects of heart rate control with esmolol in patients with septic shock: a pilot study,” Critical Care Medicine, vol. 41, no. 9, pp. 2162–2168, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. K. M. Gaǐdukov, A. I. Len'kin, V. V. Kuz'kov, E. V. Fot, A. A. Smetkin, and M. I. Kirov, “Central venous blood oxygen saturation and venous to arterial PCO2 difference after combined heart valve surgery,” Anesteziologiia i Reanimatologiia, no. 3, pp. 19–21, 2011. View at Google Scholar · View at Scopus
  15. J. Cuschieri, E. P. Rivers, M. W. Donnino et al., “Central venous-arterial carbon dioxide difference as an indicator of cardiac index,” Intensive Care Medicine, vol. 31, no. 6, pp. 818–822, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. G. G. Tsaousi, K. A. Karakoulas, E. N. Amaniti, I. D. Soultati, M. D. Zouka, and D. G. Vasilakos, “Correlation of central venous-arterial and mixed venous-arterial carbon dioxide tension gradient with cardiac output during neurosurgical procedures in the sitting position,” European Journal of Anaesthesiology, vol. 27, no. 10, pp. 882–889, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Dimopoulos, M. Theodorakopoulou, A. Armaganidis et al., “Esmolol: immunomodulator in pyelonephritis by Pseudomonas aeruginosa,” Journal of Surgical Research, vol. 198, no. 1, pp. 175–184, 2015. View at Publisher · View at Google Scholar · View at Scopus