The Effect of Esmolol on Tissue Perfusion and Clinical Prognosis of Patients with Severe Sepsis: A Prospective Cohort Study

Table 3

The effect of esmolol on hemodynamics in patients with severe sepsis.

(Time, H)	Esmolol group (); Mean ± standard deviation	Control group (); Mean ± standard deviation
Fluid intake
24 h	4373.36 ± 571.86	4841.75 ± 658.89	−4.663	<0.01
48 h	4189.61 ± 515.52	4720.74 ± 648.60	−5.566	<0.01
72 h	3991.08 ± 486.73	4553.20 ± 591.72	−6.371	<0.01
HR
Base value	125.04 ± 13.28	127.21 ± 13.88	−0.982	0.328
24 h	101.96 ± 7.36	110.12 ± 8.59	−6.272	<0.01
48 h	93.04 ± 4.52	102.57 ± 6.91	−10.039	<0.01
72 h	84.17 ± 6.26	94.47 ± 7.91	−8.861	<0.01
MAP
Base value	74.71 ± 7.28	75.89 ± 6.61	−1.051	0.295
24 h	68.65 ± 9.72	68.54 ± 7.69	0.080	0.936
48 h	71.00 ± 11.80	68.39 ± 7.53	1.615	0.109
72 h	70.91 ± 10.57	68.14 ± 7.73	1.829	0.069
CVP
Base value	12.45 ± 3.16	11.99 ± 3.35	0.881	0.380
24 h	10.04 ± 1.72	10.04 ± 1.71	0.002	0.998
48 h	10.08 ± 1.43	9.83 ± 1.23	1.158	0.249
72 h	9.77 ± 1.60	9.91 ± 1.64	−0.510	0.611
IS
Base value	10.99 ± 2.08	11.11 ± 1.81	−0.374	0.709
24 h	10.92 ± 1.39	10.74 ± 1.40	0.794	0.428
48 h	9.56 ± 1.18	9.51 ± 1.44	0.243	0.808
72 h	9.09 ± 1.24	9.29 ± 1.23	−0.957	0.340