The Effect of Esmolol on Tissue Perfusion and Clinical Prognosis of Patients with Severe Sepsis: A Prospective Cohort Study

Table 5

One-way analysis of variance with repeated measures between the two groups.

Mean ± standard deviation
Group	Base value	24 h	48 h	72 h
HR, bpm
Esmolol group	125.04 ± 13.28	101.96 ± 7.36	93.04 ± 4.52	84.17 ± 6.26	<0.001
Control group	127.21 ± 13.88	110.12 ± 8.59	102.57 ± 6.91	94.47 ± 7.91
MAP, mmHg
Esmolol group	74.71 ± 7.28	68.65 ± 9.72	71.00 ± 11.80	70.91 ± 10.57	0.277
Control group	75.89 ± 6.61	68.54 ± 7.69	68.39 ± 7.53	68.14 ± 7.73
CVP, mmHg
Esmolol group	12.45 ± 3.16	10.04 ± 1.72	10.08 ± 1.43	9.77 ± 1.60	0.385
Control group	11.99 ± 3.35	10.04 ± 1.71	9.83 ± 1.23	9.91 ± 1.64
IS
Esmolol group	10.99 ± 2.08	10.92 ± 1.39	9.56 ± 1.18	9.09 ± 1.24	0.881
Control group	11.11 ± 1.81	10.74 ± 1.40	9.51 ± 1.44	9.29 ± 1.23
Fluid intake, mL/24 h
Esmolol group		4373.36 ± 571.86	4189.61 ± 515.52	3991.08 ± 486.73	<0.001
Control group		4841.75 ± 658.89	4720.74 ± 648.60	4553.20 ± 591.72
Lac, mmol/L
Esmolol group	8.98 ± 3.09	6.62 ± 2.43	3.87 ± 1.89	2.32 ± 0.98	0.705
Control group	9.74 ± 4.05	6.82 ± 2.43	3.10 ± 1.90	2.401 ± 1.07
P(va)CO2, mmHg
Esmolol group	9.54 ± 3.89	6.71 ± 3.29	5.11 ± 2.10	2.73 ± 1.08	0.017
Control group	10.12 ± 3.52	7.26 ± 3.34	5.94 ± 2.38	3.06 ± 1.73
ScvO2
Esmolol group	0.7712 ± 0.0566	0.8000 ± 0.0529	0.7932 ± 0.0441	0.7957 ± 0.0362	<0.001
Control group	0.7762 ± 0.0592	0.7679 ± 0.0510	0.7657 ± 0.0569	0.7636 ± 0.0551