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BioMed Research International
Volume 2016, Article ID 1208476, 8 pages
Research Article

Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure

1Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China
2Department of Cardio-Thoracic Surgery, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China
3Surgery Center, 302 Hospital, Beijing 100039, China
4Information Department, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China
5Department of Pharmacy, The First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an 710061, China

Received 24 October 2015; Revised 12 January 2016; Accepted 20 January 2016

Academic Editor: Betti Giusti

Copyright © 2016 Gong-Hao He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The pathophysiological functions of cardiac histamine level and related histamine receptors during the development of chronic heart failure (CHF) were intensively investigated previously. However, the relevance of polymorphisms in histamine-related genes, such as HRH2, HRH3, DAO, and HNMT, with CHF remains largely neglected. This study herein aims to analyze the clinical associations of polymorphisms in those genes with CHF risk. A total of 333 unrelated Chinese Han CHF patients and 354 ethnicity-matched healthy controls were recruited and 11 single nucleotide polymorphisms (SNPs) were genotyped. We found that the HRH3 rs3787429 polymorphism was associated with CHF risk (). The T allele of rs3787429 exhibited protective effect against CHF under the dominant (ORs = 0.455; 95% CIs = 0.322–0.642) and additive models (ORs = 0.662; 95% CIs = 0.523–0.838), while, for SNPs in HRH2, DAO, and HNMT, no significant associations were observed in the present study. These findings for the first time screen out one SNP (rs3787429) of HRH3 gene that was significantly associated with CHF in Chinese Han population, which may be a novel biomarker for personal prevention and treatment of CHF and provides novel highlights for investigating the contribution of this disease.