G-1639A but Not C1173T VKORC1 Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population
Table 2
Genotypes distribution of VKORC1 G-1639A polymorphism in patients with IS and control subjects with different risk factors.
Group
Genotype
G/G (%) (95% CI)
G/A (%) (95% CI)
A/A (%) (95% CI)
Total
IS
170
49 (28.8) (22.0–35.6)
79 (46.5) (40.0–54.0)
42 (24.7) (18.2–31.2)
0.027
Control
124
54 (43.6) (34.8–52.3)
49 (39.5) (30.9–48.1)
21 (16.9) (10.3–23.5)
Gender
Women
IS
72
18 (25.0) (15.0–35.0)
39 (54.2) (42.7–65.7)
15 (20.8) (11.5–30.2)
0.228
Control
45
18 (40.0) (25.7–54.3)
20 (44.4) (29.9–59.0)
7 (15.6) (5.0–26.2)
Men
IS
98
31 (31.6) (22.4–40.8)
40 (40.8) (31.1–50.6)
27 (27.6) (18.7–36.4)
0.119
Control
79
36 (45.6) (34.6–56.6)
29 (36.7) (26.1–47.3)
14 (17.7) (9.3–26.1)
BMI
BMI < 25 kg/m2
IS
41
10 (24.4) (11.3–37.5)
22 (53.7) (38.4–68.9)
9 (22.0) (9.3–34.6)
0.629
Control
38
13 (34.2) (19.1–49.3)
18 (47.4) (31.5–63.2)
7 (18.4) (6.1–30.8)
BMI ≥ 25 kg/m2
IS
129
39 (30.2) (22.3–38.2)
57 (44.2) (35.6–52.8)
33 (25.6) (18.1–33.1)
0.025
Control
85
41 (48.2) (37.6–58.9)
30 (35.3) (25.1–45.5)
14 (16.5) (8.6–24.4)
Arterial blood pressure
Nonhypertensive
IS
42
14 (33.3) (19.1–47.6)
19 (45.2) (30.2–60.3)
9 (21.5) (9.0–33.8)
0.852
Control
48
17 (35.4) (21.9–49.0)
19 (39.6) (25.8–53.4)
12 (25.0) (12.8–37.3)
Hypertensive
IS
128
35 (27.3) (19.6–35.1)
60 (46.9) (38.2–55.5)
33 (25.8) (18.2–33.4)
0.003
Control
73
36 (49.3) (37.9–60.8)
29 (39.7) (28.5–51.0)
8 (11.0) (3.8–18.1)
: number of subjects in the subgroups. : the likelihood of differences between IS patients and control group by the -criterion. 95% CI: 95% confidence interval.
