G-1639A but Not C1173T VKORC1 Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population
Table 3
Analysis of G-1639A genotypic association with IS under four common models of inheritance.
Model
(95% CI)
(95% CI)
AIC
Total
Dominant
0.009
1.905 (1.172–3.097)
0.015
2.138 (1.157–3.953)
19.27
Recessive
0.111
1.609 (0.897–2.888)
0.142
1.780 (0.824–3.847)
23.46
Overdominant
0.235
1.329 (0.831–2.125)
0.226
1.434 (0.800–2.571)
24.66
Additive
0.032
1.777 (1.050–3.006)
0.041
1.979 (1.029–3.805)
20.83
0.017
2.204 (1.149–4.227)
0.028
2.621 (1.110–6.191)
Gender
Women
Dominant
0.090
2.000 (0.899–4.452)
0.038
2.848 (1.058–7.665)
15.94
Recessive
0.479
1.429 (0.533–3.832)
0.520
1.498 (0.437–5.135)
18.31
Overdominant
0.307
1.477 (0.699–3.124)
0.133
2.046 (0.804–5.207)
17.78
Additive
0.122
1.950 (0.836–4.549)
0.049
2.888 (1.006–8.293)
17.91
0.178
2.143 (0.706–6.501)
0.149
2.747 (0.697–10.826)
Men
Dominant
0.058
1.809 (0.979–3.344)
0.082
2.102 (0.911–4.582)
18.08
Recessive
0.126
1.766 (0.853–3.656)
0.196
1.958 (0.708–5.415)
19.27
Overdominant
0.578
1.189 (0.646–2.187)
0.521
1.292 (0.591–2.823)
21.37
Additive
0.173
1.602 (0.813–3.154)
0.166
1.872 (0.770–4.551)
19.40
0.049
2.240 (1.002–5.007)
0.077
2.830 (0.894–8.959)
BMI
BMI < 25 kg/m2
Dominant
0.339
1.612 (0.606–4.288)
0.519
1.521 (0.426–5.434)
14.98
Recessive
0.697
1.246 (0.413–3.758)
0.898
0.907 (0.203–4.062)
15.75
Overdominant
0.577
1.287 (0.531–3.116)
0.500
1.481 (0.474–4.625)
15.59
Additive
0.380
1.589 (0.565–4.465)
0.479
1.615 (0.428–6.086)
16.98
0.434
1.671 (0.462–6.051)
0.801
1.252 (0.218–7.183)
BMI ≥ 25 kg/m2
Dominant
0.008
2.150 (1.219–3.793)
0.016
2.391 (1.180–4.843)
18.11
Recessive
0.118
1.743 (0.869–3.498)
0.090
2.230 (0.882–5.638)
22.61
Overdominant
0.196
1.451 (0.825–2.552)
0.282
1.457 (0.734–2.892)
23.47
Additive
0.029
1.997 (1.072–3.723)
0.054
2.107 (0.989–4.489)
19.81
0.020
2.478 (1.155–5.317)
0.021
3.304 (1.199–9.106)
Arterial blood pressure
Nonhypertensive
Dominant
0.836
1.097 (0.458–2.625)
0.228
1.966 (0.655–5.904)
15.77
Recessive
0.690
0.818 (0.306–2.191)
0.612
0.717 (0.199–2.588)
15.66
Overdominant
0.588
1.261 (0.545–2.918)
0.114
2.382 (0.811–6.997)
15.52
Additive
0.689
1.214 (0.469–3.143)
0.161
2.268 (0.722–7.123)
17.49
0.870
0.911 (0.298–2.782)
0.725
0.778 (0.192–3.154)
Hypertensive
Dominant
0.002
2.585 (1.417–4.717)
0.029
2.374 (1.091–5.166)
19.72
Recessive
0.015
2.822 (1.255–6.501)
0.049
2.862 (1.003–8.169)
22.64
Overdominant
0.327
1.339 (0.747–2.399)
0.574
1.230 (0.598–2.528)
28.46
Additive
0.021
2.128 (1.119–4.046)
0.095
2.042 (0.844–4.720)
19.26
0.002
4.243 (1.722–10.453)
0.029
4.029 (1.153–14.077)
CI: confidence interval; AIC: Akaike information criterion; : observed value; : observed odds ratio; : value adjusted for covariates of age, gender, smoking status, body mass index, and hypertension in total group; for age, smoking status, body mass index, and hypertension in gender group; for age, gender, smoking status, and hypertension in BMI group; for age, gender, smoking status, and body mass index in hypertension group; : odds ratio adjusted for covariates. First row in additive model describes comparison of heterozygous genotype with major homozygous genotype and second row comparison of minor homozygous genotype with major homozygous genotype.
