G-1639A but Not C1173T VKORC1 Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population
Table 6
Clinical characteristics of IS patients with different VKORC1 G-1639A genotypes.
Parameter
G/G
G/A
A/A
Total
49
79
42
170
—
BMI
27.9 ± 3.9
28.6 ± 4.9
27.8 ± 3.6
28.2 ± 4.3
0.533
Systolic BP, mmHg
164.1 ± 32.5
169.7 ± 29.3
165.2 ± 24.8
166.9 ± 29.2
0.522
Diastolic BP, mmHg
94.9 ± 15.3
96.4 ± 15.4
93.9 ± 16.4
95.4 ± 15.6
0.692
Total cholesterol, mmol/L
5.09 ± 1.5
5.02 ± 1.5
5.06 ± 1.6
5.05 ± 1.5
0.961
HDL-cholesterol, mmol/L
1.07 ± 0.3
1.01 ± 0.3
0.99 ± 0.3
1.02 ± 0.3
0.452
LDL-cholesterol, mmol/L
3.29 ± 1.4
3.24 ± 1.4
3.24 ± 1.5
3.26 ± 1.4
0.979
Triglyceride, mmol/L
1.62 ± 0.7
1.69 ± 0.8
1.80 ± 0.9
1.70 ± 0.8
0.588
Prothrombin time, s
9.68 ± 1.9
9.51 ± 2.0
9.17 ± 2.2
9.48 ± 2.0
0.483
Thrombin time, s
16.48 ± 3.2
17.25 ± 4.1
15.26 ± 2.5
16.54 ± 3.6
0.013
Fibrinogen, g/L
3.79 ± 1.3
3.89 ± 1.3
4.17 ± 1.1
3.93 ± 1.2
0.301
Fasting glucose, mmol/L
5.82 ± 1.4
6.11 ± 1.6
5.70 ± 1.5
5.92 ± 1.5
0.312
: number of subjects; HDL: high density lipoprotein; LDL: low density lipoprotein. for G/G genotype, for G/A genotype, and for A/A genotype. Significant difference between A/A and G/A genotypes () by Bonferroni’s correction.
