Gene Expression Profile of Colon Mucosa after Cytotoxic Insult in wt and Apc-Mutated Pirc Rats: Possible Relation to Resistance to Apoptosis during Carcinogenesis

Figure 2

Unsupervised hierarchical cluster analysis based on the 101 genes significantly changed in the wt strain () after DMH and with FC ≥ 3 by microarray technique. Genes are listed in rows. In columns, the individual expressions of 6 DMH-treated wt rats (numeric code) or 2 pooled Pirc RNA are reported. Cluster 1 comprises 21 genes that were overexpressed in wt rats but not changed in Pirc rats; cluster 2 comprises 7 genes that, after DMH treatment, were downregulated in wt rats and overexpressed in Pirc rats. Note that the unsupervised analysis was able to separate Pirc from wt rats (columns).