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BioMed Research International
Volume 2016, Article ID 1358142, 7 pages
Research Article

Optimization to the Culture Conditions for Phellinus Production with Regression Analysis and Gene-Set Based Genetic Algorithm

1College of Computer and Communication Engineering, China University of Petroleum, Qingdao, Shandong 266580, China
2Center for Bioengineering and Biotechnology, China University of Petroleum, Qingdao, Shandong 266580, China

Received 28 May 2016; Revised 11 July 2016; Accepted 16 July 2016

Academic Editor: Quan Zou

Copyright © 2016 Zhongwei Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Phellinus is a kind of fungus and is known as one of the elemental components in drugs to avoid cancers. With the purpose of finding optimized culture conditions for Phellinus production in the laboratory, plenty of experiments focusing on single factor were operated and large scale of experimental data were generated. In this work, we use the data collected from experiments for regression analysis, and then a mathematical model of predicting Phellinus production is achieved. Subsequently, a gene-set based genetic algorithm is developed to optimize the values of parameters involved in culture conditions, including inoculum size, PH value, initial liquid volume, temperature, seed age, fermentation time, and rotation speed. These optimized values of the parameters have accordance with biological experimental results, which indicate that our method has a good predictability for culture conditions optimization.