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BioMed Research International
Volume 2016, Article ID 1361508, 9 pages
http://dx.doi.org/10.1155/2016/1361508
Research Article

First Report of Eurycoma longifolia Jack Root Extract Causing Relaxation of Aortic Rings in Rats

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 16 June 2016; Revised 12 August 2016; Accepted 14 September 2016

Academic Editor: Guoyan Yang

Copyright © 2016 Bae Huey Tee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. H. Ang, “Eurycoma longifolia Jack (Tongkat Ali),” in Herbal and Traditional Medicine: Molecular Aspects of Health, L. Packer, C. N. Ong, and B. Halliwell, Eds., pp. 643–656, Marcel Dekker, New York, NY, USA, 2004. View at Google Scholar
  2. W. G. Goreja, Tongkat Ali: The Tree That Cures a Hundred Diseases, Amazing Herbs Press, New York, NY, USA, 2004.
  3. M. Z. Abdullah, A. S. A. Rahman, A. Y. M. Shakaff, and A. M. Noor, “Discrimination and classification of Eurycoma longifolia Jack in medicinal foods by means of a DSP-based electronic taste sensor,” Transactions of the Institute of Measurement and Control, vol. 26, no. 1, pp. 19–39, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Bhat and A. A. Karim, “Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance,” Fitoterapia, vol. 81, no. 7, pp. 669–679, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Tada, F. Yasuda, K. Otani, M. Doteuchi, Y. Ishihara, and M. Shiro, “New antiulcer quassinoids from Eurycoma longifolia,” European Journal of Medicinal Chemistry, vol. 26, no. 3, pp. 345–349, 1991. View at Publisher · View at Google Scholar · View at Scopus
  6. L. B. S. Kardono, C. K. Angerhofer, S. Tsauri, K. Padmawinata, J. M. Pezzuto, and A. D. Kinghorn, “Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia,” Journal of Natural Products, vol. 54, no. 5, pp. 1360–1367, 1991. View at Publisher · View at Google Scholar · View at Scopus
  7. H. H. Ang, K. L. Chan, and J. W. Mak, “In vitro antimalarial activity of quassinoids from Eurycoma longifolia against Malaysian chloroquine-resistant Plasmodium falciparum isolates,” Planta Medica, vol. 61, no. 2, pp. 177–178, 1995. View at Publisher · View at Google Scholar · View at Scopus
  8. P.-C. Kuo, A. G. Damu, K.-H. Lee, and T.-S. Wu, “Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia,” Bioorganic and Medicinal Chemistry, vol. 12, no. 3, pp. 537–544, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. H. H. Ang, S. Ikeda, and E. K. Gan, “Evaluation of the potency activity of aphrodisiac in Eurycoma longifolia Jack,” Phytotherapy Research, vol. 15, no. 5, pp. 435–436, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. H. H. Ang and M. K. Sim, “Eurycoma longifolia Jack enhances libido in sexually experienced male rats,” Experimental Animals, vol. 46, no. 4, pp. 287–290, 1997. View at Publisher · View at Google Scholar · View at Scopus
  11. H. H. Ang and M. K. Sim, “Effects of Eurycoma longifolia Jack on penile erection index and homosexual mounting in rats,” Pharmacy and Pharmacology Communications, vol. 3, no. 2, pp. 117–119, 1997. View at Google Scholar · View at Scopus
  12. K.-L. Chan, B.-S. Low, C.-H. Teh, and P. K. Das, “The effect of Eurycoma longifolia on sperm quality of male rats,” Natural Product Communications, vol. 4, no. 10, pp. 1331–1336, 2009. View at Google Scholar · View at Scopus
  13. S. B. Ismail, W. M. Z. Wan Mohammad, A. George, N. H. Nik Hussain, Z. M. Musthapa Kamal, and E. Liske, “Randomized clinical trial on the use of PHYSTA freeze-dried water extract of Eurycoma longifolia for the improvement of quality of life and sexual well-being in men,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 429268, 10 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Zanoli, M. Zavatti, C. Montanari, and M. Baraldi, “Influence of Eurycoma longifolia on the copulatory activity of sexually sluggish and impotent male rats,” Journal of Ethnopharmacology, vol. 126, no. 2, pp. 308–313, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Lote, “The renin-angiotensin system and regulation of fluid volume,” Surgery, vol. 24, no. 5, pp. 154–159, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Guang, R. D. Phillips, B. Jiang, and F. Milani, “Three key proteases—angiotensin-I-converting enzyme (ACE, ACE2 and renin—within and beyond the renin-angiotensin system,” Archives of Cardiovascular Diseases, vol. 105, no. 6-7, pp. 373–385, 2012. View at Google Scholar
  17. G. Jagadeesh, “Angiotensin II receptors-antagonists, molecular biology, and signal transduction,” Indian Journal of Experimental Biology, vol. 36, no. 12, pp. 1171–1194, 1998. View at Google Scholar · View at Scopus
  18. M. E. Marketou and P. E. Vardas, “Bradykinin in the treatment of arterial hypertension: friend or foe?” Hellenic Journal of Cardiology, vol. 53, no. 2, pp. 91–94, 2012. View at Google Scholar · View at Scopus
  19. J. F. Riordan, “Angiotensin-I-converting enzyme and its relatives,” Genome Biology, vol. 4, no. 8, article 225, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Te Riet, J. H. M. van Esch, A. J. M. Roks, A. H. van den Meiracker, and A. H. J. Danser, “Hypertension: renin-angiotensin-aldosterone system alterations,” Circulation Research, vol. 116, no. 6, pp. 960–975, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. P. A. James, S. Oparil, B. L. Carter et al., “2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8),” The Journal of the American Medical Association, vol. 311, no. 5, pp. 507–520, 2014. View at Publisher · View at Google Scholar
  22. P. M. Kearney, M. Whelton, K. Reynolds, P. Muntner, P. K. Whelton, and J. He, “Global burden of hypertension: analysis of worldwide data,” The Lancet, vol. 365, no. 9455, pp. 217–223, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. J. He and P. K. Whelton, “Epidemiology and prevention of hypertension,” The Medical Clinics of North America, vol. 81, no. 5, pp. 1077–1097, 1997. View at Publisher · View at Google Scholar · View at Scopus
  24. R. A. Kloner, “Erectile dysfunction and cardiovascular risk factors,” in Contemporary Cardiology: Heart Disease and Erectile Dysfunction, R. A. Kloner, Ed., pp. 39–49, Humana Press, Totowa, NJ, USA, 2004. View at Google Scholar
  25. M. P. J. Nicolai, S. S. Liem, S. Both et al., “A review of the positive and negative effects of cardiovascular drugs on sexual function: a proposed table for use in clinical practice,” Netherlands Heart Journal, vol. 22, no. 1, pp. 11–19, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Viigimaa, C. Vlachopoulos, A. Lazaridis, and M. Doumas, “Management of erectile dysfunction in hypertension: tips and tricks,” World Journal of Cardiology, vol. 6, no. 9, pp. 908–915, 2014. View at Publisher · View at Google Scholar
  27. National Research Council, Guide for the Care and Use of Laboratory Animals, The National Academy Press, Washington, DC, USA, 8th edition, 2011.
  28. S.-Z. Hoe, C.-N. Lee, S.-L. Mok, M. Y. Kamaruddin, and S.-K. Lam, “Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels,” Clinics, vol. 66, no. 1, pp. 143–150, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. K. H. S. Arun, C. L. Kaul, and R. Poduri, “Tempol augments angiotensin II-induced AT2 receptor-mediated relaxation in diabetic rat thoracic aorta,” Journal of Hypertension, vol. 22, no. 11, pp. 2143–2152, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. S.-Z. Hoe, M. Y. Kamaruddin, and S.-K. Lam, “Inhibition of angiotensin-converting enzyme activity by a partially purified fraction of Gynura procumbens in spontaneously hypertensive rats,” Medical Principles and Practice, vol. 16, no. 3, pp. 203–208, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. B. H. Tee, S. Z. Hoe, S. H. Cheah, and S. K. Lam, “Effect of Eurycoma longifolia Jack on the corpus cavernosum smooth muscle of rats,” Current Medicinal Chemistry, pp. 161–162, 2011. View at Google Scholar
  32. M. J. Peach, “Renin-angiotensin system: biochemistry and mechanisms of action,” Physiological Reviews, vol. 57, no. 2, pp. 313–370, 1977. View at Google Scholar
  33. C. Egleme, F. Cressier, and J. M. Wood, “Local formation of angiotensin II in the rat aorta: effect of endothelium,” British Journal of Pharmacology, vol. 100, no. 2, pp. 237–240, 1990. View at Publisher · View at Google Scholar · View at Scopus
  34. R. Leite, R. Estevao, A. C. Resende, and M. C. O. Salgado, “Role of endothelium in angiotensin II formation by the rat aorta and mesenteric arterial bed,” Brazilian Journal of Medical and Biological Research, vol. 30, no. 5, pp. 649–656, 1997. View at Google Scholar · View at Scopus
  35. S. Y. Fukada, C. R. Tirapelli, M. A. F. De Godoy, and A. M. De Oliveira, “Mechanisms underlying the endothelium-independent relaxation induced by anqiotensin II in rat aorta,” Journal of Cardiovascular Pharmacology, vol. 45, no. 2, pp. 136–143, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Dimitropoulou, R. E. White, L. Fuchs, H. Zhang, J. D. Catravas, and G. O. Carrier, “Angiotensin II relaxes microvessels via the AT2 receptor and Ca2+-activated K+ (BKCa) channels,” Hypertension, vol. 37, no. 2, pp. 301–307, 2001. View at Publisher · View at Google Scholar
  37. R. M. Carey, Z.-Q. Wang, and H. M. Siragy, “Role of the angiotensin type 2 receptor in the regulation of blood pressure and renal function,” Hypertension, vol. 35, no. 1, part 2, pp. 155–163, 2000. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Dharmashankar and M. E. Widlansky, “Vascular endothelial function and hypertension: insights and directions,” Current Hypertension Reports, vol. 12, no. 6, pp. 448–455, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. I. Duka, E. Kintsurashvili, I. Gavras, C. Johns, M. Bresnahan, and H. Gavras, “Vasoactive potential of the B1 bradykinin receptor in normotension and hypertension,” Circulation Research, vol. 88, no. 3, pp. 275–281, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Duka, I. Duka, G. Gao, S. Shenouda, I. Gavras, and H. Gavras, “Role of bradykinin B1 and B2 receptors in normal blood pressure regulation,” American Journal of Physiology—Endocrinology and Metabolism, vol. 291, no. 2, pp. E268–E274, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. L. Murphey, D. Vaughan, and N. Brown, “Contribution of bradykinin to the cardioprotective effects of ACE inhibitors,” European Heart Journal, vol. 5, supplement, pp. A37–A41, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. T. Ignjatovic, F. Tan, V. Brovkovych, R. A. Skidgel, and E. G. Erdös, “Activation of bradykinin B1 receptor by ACE inhibitors,” International Immunopharmacology, vol. 2, no. 13-14, pp. 1787–1793, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. E. G. Erdös, F. Tan, and R. A. Skidgel, “Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function,” Hypertension, vol. 55, no. 2, pp. 214–220, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. K. M. Gauthier, C. J. Cepura, and W. B. Campbell, “ACE inhibition enhances bradykinin relaxations through nitric oxide and B1 receptor activation in bovine coronary arteries,” Biological Chemistry, vol. 394, no. 9, pp. 1205–1212, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. M. P. Ocaranza, L. Michea, M. Chiong, C. F. Lagos, S. Lavandero, and J. E. Jalil, “Recent insights and therapeutic perspectives of angiotensin-(1–9) in the cardiovascular system,” Clinical Science, vol. 127, no. 9, pp. 549–557, 2014. View at Publisher · View at Google Scholar · View at Scopus
  46. M. P. Ocaranza, J. Moya, V. Barrientos et al., “Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis,” Journal of Hypertension, vol. 32, no. 4, pp. 771–783, 2014. View at Publisher · View at Google Scholar · View at Scopus