Molecular Imaging for Comparison of Different Growth Factors on Bone Marrow-Derived Mesenchymal Stromal Cells’ Survival and Proliferation In Vivo

Figure 5

In vivo experiment. (a) DAB assay analysis of the efficacy of VEGF, IGF-1, and bFGF plus matrigel in vivo; the apoptotic nuclei shrank and turned brown. (b) Apoptosis index of BMSCs treated with VEGF, IGF-1, and bFGF, respectively, compared with control; BMSCs treated with either matrigel plus bFGF or matrigel plus IGF-1 extended BMSCs’ survival (% and % versus %), while matrigel plus VEGF was %; (c) p-Akt/Akt ratio of BMSCs treated with VEGF, IGF-1, and bFGF, respectively; BMSCs treated with matrigel plus bFGF and matrigel plus IGF-1 showed higher ratio of p-Akt/Akt compared with control ( and versus ), while matrigel plus VEGF group was ; versus control; in each group. Bar scale = 40 μm.

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