Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 1375858, 5 pages
http://dx.doi.org/10.1155/2016/1375858
Review Article

Crosstalk between Vitamin D Metabolism, VDR Signalling, and Innate Immunity

Department of Digestive Diseases, General Hospital, Tianjin Medical University, Tianjin 300052, China

Received 16 May 2016; Accepted 30 May 2016

Academic Editor: Guan Yang

Copyright © 2016 Rui Lin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Bouillon, G. Carmeliet, L. Verlinden et al., “Vitamin D and human health: lessons from vitamin D receptor null mice,” Endocrine Reviews, vol. 29, no. 6, pp. 726–776, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Hewison, “An update on vitamin D and human immunity,” Clinical Endocrinology, vol. 76, no. 3, pp. 315–325, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. V. P. Walker and R. L. Modlin, “The vitamin D connection to pediatric infections and immune function,” Pediatric Research, vol. 65, no. 5, pp. 106R–113R, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. M. F. Holick, “Vitamin D deficiency,” The New England Journal of Medicine, vol. 357, no. 3, pp. 266–281, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. J. S. Adams and M. Hewison, “Update in vitamin D,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 2, pp. 471–478, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Lamberg-Allardt, “Vitamin D in foods and as supplements,” Progress in Biophysics and Molecular Biology, vol. 92, no. 1, pp. 33–38, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. L. E. Tavera-Mendoza and J. H. White, “Cell defenses and the sunshine vitamin,” Scientific American, vol. 297, no. 5, pp. 62–72, 2007. View at Google Scholar · View at Scopus
  8. L. Tripkovic, H. Lambert, K. Hart et al., “Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis,” American Journal of Clinical Nutrition, vol. 95, no. 6, pp. 1357–1364, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. T. J. Wang, F. Zhang, J. B. Richards et al., “Common genetic determinants of vitamin D insufficiency: a genome-wide association study,” The Lancet, vol. 376, no. 9736, pp. 180–188, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Zehnder, “Extrarenal expression of 25-hydroxyvitamin D3-1,” The Journal of Clinical Endocrinology & Metabolism, vol. 86, no. 2, pp. 888–894, 2001. View at Google Scholar
  11. A. C. Ross, J. E. Manson, S. A. Abrams et al., “The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know,” Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 1, pp. 53–58, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. R. P. Heaney and M. F. Holick, “Why the IOM recommendations for vitamin D are deficient,” Journal of Bone and Mineral Research, vol. 26, no. 3, pp. 455–457, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Lin and J. H. White, “The pleiotropic actions of vitamin D,” BioEssays, vol. 26, no. 1, pp. 21–28, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Matthews, E. LaPorta, G. M. Zinser, C. J. Narvaez, and J. Welsh, “Genomic vitamin D signaling in breast cancer: insights from animal models and human cells,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 121, no. 1-2, pp. 362–367, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. J. M. Matilainen, T. Husso, S. Toropainen et al., “Primary effect of 1α,25(OH)2D3 on IL-10 expression in monocytes is short-term down-regulation,” Biochimica et Biophysica Acta (BBA)—Molecular Cell Research, vol. 1803, no. 11, pp. 1276–1286, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. F. J. Dilworth and P. Chambon, “Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription,” Oncogene, vol. 20, no. 24, pp. 3047–3054, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. M. B. Meyer, P. D. Goetsch, and J. W. Pike, “A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1α,25-dihydroxyvitamin D3,” Journal of Biological Chemistry, vol. 285, no. 20, pp. 15599–15610, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. B.-S. An, L. E. Tavera-Mendoza, V. Dimitrov et al., “Stimulation of sirt1-regulated foxo protein function by the ligand-bound vitamin d receptor,” Molecular and Cellular Biology, vol. 30, no. 20, pp. 4890–4900, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Grad, “Cod and the consumptive: a brief history of cod-liver oil in the treatment of pulmonary tuberculosis,” Pharmacy in History, vol. 46, no. 3, pp. 106–120, 2004. View at Google Scholar · View at Scopus
  20. A. F. Gombart, N. Borregaard, and H. P. Koeffler, “Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3,” FASEB Journal, vol. 19, no. 9, pp. 1067–1077, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. P. T. Liu, S. Stenger, H. Li et al., “Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response,” Science, vol. 311, no. 5768, pp. 1770–1773, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Edfeldt, P. T. Liu, R. Chun et al., “T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 52, pp. 22593–22598, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Ramanathan, E. G. Davis, C. R. Ross, and F. Blecha, “Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity,” Microbes and Infection, vol. 4, no. 3, pp. 361–372, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. O. Sørensen, J. B. Cowland, J. Askaa, and N. Borregaard, “An ELISA for hCAP-18, the cathelicidin present in human neutrophils and plasma,” Journal of Immunological Methods, vol. 206, no. 1-2, pp. 53–59, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Jeng, A. V. Yamshchikov, S. E. Judd et al., “Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis,” Journal of Translational Medicine, vol. 7, no. 1, article 28, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Baeke, T. Takiishi, H. Korf, C. Gysemans, and C. Mathieu, “Vitamin D: modulator of the immune system,” Current Opinion in Pharmacology, vol. 10, no. 4, pp. 482–496, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Müller, M. Diamant, and K. Bendtzen, “Inhibition of production and function of interleukin-6 by 1,25-dihydroxyvitamin D3,” Immunology Letters, vol. 28, no. 2, pp. 115–120, 1991. View at Publisher · View at Google Scholar · View at Scopus
  28. E. Y. Enioutina, D. Bareyan, and R. A. Daynes, “TLR-induced local metabolism of vitamin D3 plays an important role in the diversification of adaptive immune responses,” The Journal of Immunology, vol. 182, no. 7, pp. 4296–4305, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. A. K. Coussens, R. J. Wilkinson, Y. Hanifa et al., “Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 38, pp. 15449–15454, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Froicu and M. T. Cantorna, “Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury,” BMC Immunology, vol. 8, article 5, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. J. H. Ooi, Y. Li, C. J. Rogers, and M. T. Cantorna, “Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate-induced coliti,” Journal of Nutrition, vol. 143, no. 10, pp. 1679–1686, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. H. G. Pálmer, J. M. González-Sancho, J. Espada et al., “Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling,” The Journal of Cell Biology, vol. 154, no. 2, pp. 369–387, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. T.-T. Wang, F. P. Nestel, V. Bourdeau et al., “Cutting edge: 1,25-Dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression,” Journal of Immunology, vol. 173, no. 5, pp. 2909–2912, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. R. E. W. Hancock and H.-G. Sahl, “Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies,” Nature Biotechnology, vol. 24, no. 12, pp. 1551–1557, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. E. D'Aldebert, M.-J. Biyeyeme Bi Mve, M. Mergey et al., “Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium,” Gastroenterology, vol. 136, no. 4, pp. 1435–1443, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. A. F. Gombart, T. Saito, and H. P. Koeffler, “Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates,” BMC Genomics, vol. 10, article 321, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. P. T. Liu, M. Schenk, V. P. Walker et al., “Convergence of IL-1β and VDR activation pathways in human TLR2/1-induced antimicrobial responses,” PLoS ONE, vol. 4, no. 6, Article ID e5810, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. T.-T. Wang, B. Dabbas, D. Laperriere et al., “Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin β2 innate immune pathway defective in Crohn disease,” The Journal of Biological Chemistry, vol. 285, no. 4, pp. 2227–2231, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. E. Voss, J. Wehkamp, K. Wehkamp, E. F. Stange, J. M. Schröder, and J. Harder, “NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2,” The Journal of Biological Chemistry, vol. 281, no. 4, pp. 2005–2011, 2006. View at Publisher · View at Google Scholar · View at Scopus