Comparison of the Effects of Dibutyl and Monobutyl Phthalates on the Steroidogenesis of Rat Immature Leydig Cells

Table 1

The effects of dibutyl phthalate (DBP) and monobutyl phthalate (MBP) on androgen production in rat immature Leydig cells.

	Androstanediol (ng/10^6 cells/3 h)			Testosterone (ng/10^6 cells/3 h)
	Control	DBP	MBP	Control	DBP	MBP
Basal
LH
8BR-cAMP
22R-OH-cholesterol
Pregnenolone
Progesterone
Androstenedione
Testosterone				ND	ND	ND
Dihydrotestosterone				ND	ND	ND

Mean ± SEM, = 4~12. ND = not detected. Identical letters indicate that there are no significant differences between two groups for either androstanediol or testosterone production.