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BioMed Research International
Volume 2016, Article ID 1390620, 7 pages
http://dx.doi.org/10.1155/2016/1390620
Clinical Study

Influence of APOE Genotype on Alzheimer’s Disease CSF Biomarkers in a Spanish Population

1Department of Neurology, University General Hospital of Alicante, Avenida Pintor Baeza 12, 03010 Alicante, Spain
2Genetics Laboratory, University General Hospital of Alicante, Avenida Pintor Baeza 12, 03010 Alicante, Spain
3Immunology Laboratory, University General Hospital of Alicante, Avenida Pintor Baeza 12, 03010 Alicante, Spain
4Department of Preventive Medicine, University General Hospital of Alicante, Avenida Pintor Baeza 12, 03010 Alicante, Spain

Received 6 August 2015; Revised 9 October 2015; Accepted 25 November 2015

Academic Editor: Grazia D’Onofrio

Copyright © 2016 J. A. Monge-Argilés et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To evaluate the association between apolipoprotein E (APOE) genotype and cerebrospinal fluid (CSF) levels of Alzheimer’s disease (AD) biomarkers and to study the influence of APOE genotype on the development of AD in a Spanish population. Material and Methods. The study comprised 29 amnestic mild cognitive impairment (MCI) patients and 27 control subjects. Using ELISA methodology, CSF biomarkers and tau/Aβ ratios were obtained. ANOVA and adjusted odds ratios were calculated. Results. We observed the effect of APOE genotype and age on CSF AD variables. The progression to AD was more clearly influenced by CSF AD variables than by age or APOE status. Conclusions. APOE status influences CSF AD variables. However, the presence of APOE ε4 does not appear to be a deterministic factor for the development of AD, because CSF variables have a greater influence on progression to the disease. These results confirm previous observations and, to our knowledge, are the first published in a Spanish population.