Influence of APOE Genotype on Alzheimer’s Disease CSF Biomarkers in a Spanish Population

Table 1

Demographic, clinical, and genetic characteristics of the study population.

	MCI patients	Control subjects	Significance level
Number of cases	29	27	n.s.
Gender, male (%)	38	44	n.s.
Age (mean ± SD)	70.34 ± 7.3	68.74 ± 7.5	n.s.
Medical history
HTA	16	17	—
DM	2	8
HPL	17	18
Depression	7	6
MMSE Folstein	24 ± 0.8	28.48 ± 2.5	0.05
IQCODE	82.89 ± 3.5	52.62 ± 14.9	0.01
Progression at 2 years
Stable normal	—	22	—
Stable MCI	17	—
Develop MCI	—	3
Develop AD	12 (, )	2 (, )
APOE genotype
ε2	2	8
ε3	14	18
ε4	13	1
Education (years)	5	6	n.s.

SD = standard deviation. HTA = hypertension. DM = diabetes mellitus. HPL = hyperlipidemia. MMSE = mini mental status examination. IQCODE = informant questionnaire on cognitive decline in the elderly. MCI = mild cognitive impairment. AD = Alzheimer’s disease.