Influence of APOE Genotype on Alzheimer’s Disease CSF Biomarkers in a Spanish Population

Table 2

APOE genotype influence on CSF AD biomarker variables.

CSF variables	APOE; genotype	Number of subjects	Mean ± SD	Significance level	Adjusted significance level
Aβ protein; (pg/mL)	ε2	10	1320.50 ± 489.51
	ε3	31	1178.23 ± 428.40	0.0001	0.001
	ε4	15	656.80 ± 201.96
T-tau protein; (pg/mL)	ε2	10	207.00 ± 110.89
	ε3	31	259.39 ± 130.60	0.0001	0.004
	ε4	15	488.27 ± 284.34
			Median (25–75)
p-tau protein; (pg/mL)	ε2	10	38 (30.27–42.73)
	ε3	31	44 (42.97–63.94)	0.06	0.02
	ε4	15	71 (57.0–95.17)
Ratio; T-tau/Aβ	ε2	10	0.14 (0.08–0.26)
	ε3	31	0.18 (0.19–0.34)	0.18	0.0001
	ε4	15	0.74 (0.55–1.06)
Ratio; p-tau/Aβ	ε2	10	0.03 (0.02–0.03)
	ε3	31	0.03 (0.03–0.07)	0.09	0.0001
	ε4	15	0.11 (0.08–0.17)

ANOVA 1 factor. Chi-square. SD: standard deviation.