Review Article
Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer
Figure 2
BLMTg reduces intestinal polyp numbers by ~2-fold in ApcMin/+ mice. Polyps counts () for different regions of the gastrointestinal tract are shown for ApcMin/+, ApcMin/+;BLMTg/+, and ApcMin/+;BLMTg/Tg mice. BLMTg dose-dependent suppression of adenoma numbers is most evident in the jejunum and ileum. BLMTg does not change tumor spectrum or location.