Metformin Alleviated Aβ-Induced Apoptosis via the Suppression of JNK MAPK Signaling Pathway in Cultured Hippocampal Neurons

Figure 3

Metformin salvaged Aβ-induced cytotoxicity via MAPK JNK signaling pathway. (a) and (b) Quantitative analysis of MTT and LDH represented that Aβ increased the phosphorylation of JNK, which could be reserved by metformin treatment (, ). In addition, anisomycin treatment blocked metformin-involved protection, suggesting the depression of JNK had a vital role in the effect of metformin.

(a)

(b)