Inhibitor of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells to Temozolomide via Activating ROS/JNK Signaling Pathway

Figure 1

NAMPT inhibitor sensitizes glioblastoma cells to TMZ treatment. (a) Upregulation of MGMT in U251-MG and T89-MG cells compared with normal human astrocyte (NHA) cells. (b) Confirmation of inhibitory effect of FK866 and CHS828 on NAD concentration in U251-MG and T89-MG cells. (c) Effects of low (5 nM) and high (100 nM) doses of FK866 on cell viability in U251-MG GBM cells. versus control. versus FK866 (5 nM). . (d) Effects of low (10 nM) and high (200 nM) doses of CHS828 on cell viability in U251-MG GBM cells. versus control. versus CHS828 (10 nM). . (e) Effects of low (5 nM) and high (100 nM) doses of FK866 on cell viability in T89 GBM cells. versus FK866 (5 nM). . (f) Effects of low (10 nM) and high (200 nM) doses of CHS828 on cell viability in T89 GBM cells.

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