Inhibitor of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells to Temozolomide via Activating ROS/JNK Signaling Pathway

Figure 6

The c-Jun/JNK pathway and ROS production contribute to the sensitization of NAMPT inhibitor on TMZ antitumor action in glioblastoma cells. (a-b) Effects of SP600125, a specific inhibitor of JNK pathway, on the antitumor action of FK866 (a) and CHS828 (b). versus FK866 (5 nM) or CHS828 (10 nM). . (c-d) Effects of tocopherol, a ROS scavenger, on the antitumor action of FK866 (c) and CHS828 (d). versus FK866 (5 nM) or CHS828 (10 nM). . versus control. versus FK866 (5 nM) or CHS828 (10 nM) alone.

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