Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension

Table 2

GMDR models of high-order gene-environment interaction in CYP11B2 promoter on EH risk.

Model	Training balanced accuracy	Testing balanced accuracy	Sign test ()	Cross-validation consistency
CpG2	0.56	0.45	3 (0.945)	6/10
CpG3, smoking	0.61	0.52	7 (0.172)	6/10
CpG1, CpG3, drinking	0.64	0.49	5 (0.623)	5/10
CpG1, CpG3, CpG4, smoking	0.68	0.60	9 (0.011)	10/10
CpG1, CpG3, CpG4, smoking, drinking	0.72	0.53	7 (0.172)	8/10
CpG1, CpG2, CpG3, CpG4, smoking, drinking	0.75	0.51	6 (0.377)	10/10

value was adjusted for age, gender, BMI, triglycerides, HDL, BUA, and Hcy using logistic regression in GMDR analysis.
GMDR: generalized multifactor dimensionality reduction; BMI: body mass index; TG: triglycerides; HDL: high-density lipoprotein; BUA: blood uric acid; Hcy: homocysteine.