Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension

Table 4

Association of promoter methylation with environmental factors in EH patients.

Variable	Gender			Age		Smoking
	Men	Women		(95% CI)		(95% CI)
CpG1			0.997	0.117 (0.049, 0.185)	0.001	−0.318 (−2.390, 1.754)	0.761
CpG2			0.997	−0.005 (−0.123, 0.117)	0.899	0.374 (−1.795, 2.544)	0.732
CpG3			1.000	−0.037 (−0.128, 0.034)	0.356	0.533 (−1.871, 2.938)	0.660
CpG4			0.992	−0.011 (−0.144, 0.122)	0.868	−1.804 (−5.850, 2.242)	0.378

was adjusted by logistic regression for age, BUA, smoking, drinking, BMI, ALP, TG, HDL, LDL, and Hcy. was calculated by multiple linear regression model including gender, age, BUA, smoking, drinking, BMI, ALP, TG, HDL, LDL, and Hcy. BMI: body mass index; ALP: alkaline phosphatase; TG: triglycerides; HDL: high-density lipoprotein; LDL: low-density lipoprotein; Hcy: homocysteine.