Expression of miRNA-122 Induced by Liver Toxicants in Zebrafish

Figure 6

Quantitative expression levels of miRNA-122 in liver toxicant-treated adult zebrafish. (a) Quantitative expression levels of miRNA-122 in tamoxifen- (or acetaminophen-) treated adult zebrafish livers. miRNA-122 expression was upregulated at 0.5 μM and 1 μM and downregulated at 2 μM tamoxifen. miRNA-122 expression was gradually upregulated at 1 mM and 2 mM and decreased at 4 mM acetaminophen. (b) Tissue-specific expression of miRNA-122. miRNA-122 was expressed in the liver of tamoxifen-treated zebrafish, but not in the brain, heart, and intestine at 0.5 μM. Error bars indicate minimum and maximum values of relative quantification ().

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