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BioMed Research International
Volume 2016 (2016), Article ID 1489050, 16 pages
http://dx.doi.org/10.1155/2016/1489050
Review Article

The Potential Therapeutic Effects of Artesunate on Stroke and Other Central Nervous System Diseases

1Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China
2Department of Neurobiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China

Received 2 August 2016; Accepted 20 November 2016

Academic Editor: Eduardo Gonzalez-Toledo

Copyright © 2016 Shilun Zuo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Artesunate is an important agent for cerebral malaria and all kinds of other severe malaria because it is highly efficient, lowly toxic, and well-tolerated. Loads of research pointed out that it had widespread pharmacological activities such as antiparasites, antitumor, anti-inflammation, antimicrobes activities. As we know, the occurrence and development of neurological disorders usually refer to intricate pathophysiologic mechanisms and multiple etiopathogenesis. Recent progress has also demonstrated that drugs with single mechanism and serious side-effects are not likely the candidates for treatment of the neurological disorders. Therefore, the pluripotent action of artesunate may result in it playing an important role in the prevention and treatment of these neurological disorders. This review provides an overview of primary pharmacological mechanism of artesunate and its potential therapeutic effects on neurological disorders. Meanwhile, we also briefly summarize the primary mechanisms of artemisinin and its derivatives. We hope that, with the evidence presented in this review, the effect of artesunate in prevention and curing for neurological disorders can be further explored and studied in the foreseeable future.