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BioMed Research International
Volume 2016 (2016), Article ID 1489204, 7 pages
http://dx.doi.org/10.1155/2016/1489204
Research Article

Penis Allotransplantation in Beagle Dog

Department of Urology, The General Hospital of Guangzhou Military Command, No. 111, Liuhua Road, Guangzhou, Guangdong 510010, China

Received 14 September 2015; Revised 30 November 2015; Accepted 10 December 2015

Academic Editor: Gerald Brandacher

Copyright © 2016 Yongbin Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This is an original research of penis allotransplantation. The paper presents an experiment allogenic penis transplantation model in Beagles, with a focus on recovery of blood supply and changes in tissue architecture. Twenty adult Beagles were allocated to 10 pairs for penile transplantation. After operation, the skin and glans were observed. If adverse symptoms occurred, the transplanted penis was resected and pathologically examined. Frequency of urination, urinary stream, and patency level were recorded 7 days after transplantation. Cystourethrography was performed on Day 10. The transplanted penises were resected on Day 14 for pathological examination. The research showed that transplanted penises survived after allotransplantation, and the dogs regained urination ability. Penis autotransplantation in Beagles is feasible. This preliminary study shows a potential for application of this new procedure for penis transplantation in humans.