The CYBA Gene 49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease

Table 4

The frequency of genotypes and alleles of the CYBA gene 49A>G polymorphism in subgroups of hypertensive CAD patients (CAD) and nonhypertensive blood donors (BD).

Genotype, allele	CAD % (n)	BD % (n)	Versus	OR (95% CI), P univariate analysis	Power (%) 95% CL
AA	13.1 (18)	22.7 (49)	GG+AG	0.48 (0.27–0.85), 0.011^1	73
AG	43.1 (59)	45.4 (98)	—	—	—
GG	43.8 (60)	31.9 (69)	AA+AG	1.66 (1.08–2.57), 0.022^2	62
AA+AG	56.2 (77)	68.1 (147)	GG	0.60 (0.39–0.93), 0.022^3	62
GG+AG	86.9 (119)	77.3 (167)	AA	2.10 (1.18–3.76), 0.011^4	73
49A	34.7 (95)	45.4 (196)	49G	0.62 (0.45–0.84), 0.002	60
49G	65.3 (179)	54.6 (236)	49A	1.61 (1.18–2.20), 0.002	60

The results of multivariate analysis after adjustment for sex, age, TC, LDL-chol, HDL-chol, TG, BMI, diabetes mellitus, cigarette smoking status, and familial history of CAD.
OR = 0.47, 95 % CI; 0.25–0.91, P = 0.024.
OR = 1.90, 95 % CI; 1.14–3.15, P = 0.012.
OR = 0.53, 95 % CI; 0.32–0.87, P = 0.012.
OR = 2.10, 95 % CI; 1.10–4.01, P = 0.024.
CAD: coronary artery disease patients, BD: blood donors, OR: odds ratio, CI; confidence interval, and CL: confidence level.