Biosensor for Hepatocellular Injury Corresponds to Experimental Scoring of Hepatosplenic Schistosomiasis in Mice
Pathological changes of the liver due to different S. mansoni infection intensities. (a) Weights of spleens and livers of infected mice groups are significantly increased compared to naive mice. Infection with 50 or 100 cercariae results in a comparable increase of spleen and liver weights. (b) The outer appearance of mice livers following infection with 50 or 100 cercariae is markedly different. Compared to the livers of naive and mice infected with 50 cercariae, the livers of mice infected with 100 cercariae appear firmer and paler with area-wide nodules, bosselations, and star-like depressions. (c) Scoring of parameters describing the outer appearance of all mice livers reveals highest score levels in mice infected with 100 cercariae compared to livers of naive mice and mice infected with 50 cercariae.