A Novel Murine Model of Parvovirus Associated Dilated Cardiomyopathy Induced by Immunization with VP1-Unique Region of Parvovirus B19

Table 2

Top 10 dysregulated transcripts.

		Fold change	value			Fold change	value
PBS versus cardiac myosin
Igkc	Immunoglobulin kappa constant	−2.47	0.04	Timp4	Tissue inhibitor of metalloproteinase 4	2.94	0.01
Tfrc	Transferrin receptor	−1.80	0.01	Pdk4	Pyruvate dehydrogenase kinase, isoenzyme	2.65	0.02
Tcrg-C4	T cell receptor gamma, constant 4	−1.68	0.04	Fkbp5	FK506 binding protein 5	2.49	0.02
Mmp3	Matrix metallopeptidase 3	−1.45	0.05	Zbtb16	Zinc finger and BTB domain containing 16	2.09	0.02
Comp	Cartilage oligomeric matrix protein	−1.36	0.05	Fam107a	Family with sequence similarity 107, mem	2.06	0.02
Rrad	Ras-related associated with diabetes	−1.33	0.02	Map3k6	Mitogen-activated protein kinase kinase	2.04	0.02
Ighm	Immunoglobulin heavy constant mu	−1.31	0.02	Ucp3	Uncoupling protein 3 (mitochondrial, pro	1.97	0.03
Gpr22	G protein-coupled receptor 22	−1.06	0.01	Cdkn1a	Cyclin-dependent kinase inhibitor 1A (p21)	1.73	0.05
Map2k6	Mitogen-activated protein kinase kinase	−1.04	0.03	Ms4a4a	Membrane-spanning 4-domain, subfamily A	1.51	0.02
Igkj5	Immunoglobulin kappa joining 5	−1.04	0.04	Klhl38	Kelch-like 38	1.45	0.04
PBS versus VP1u
Rrad	Ras-related associated with diabetes	−1.69	0.01	Fkbp5	FK506 binding protein 5	2.39	0.02
Kcnj2	Potassium inwardly-rectifying channel	−1.05	0.01	Timp4	Tissue inhibitor of metalloproteinase 4	2.04	0.03
Arhgap18	Rho GTPase activating protein 18	−1.01	0.01	Cdkn1a	Cyclin-dependent kinase inhibitor 1A (p21)	2.02	0.03
Ighm	Immunoglobulin heavy constant mu	−0.88	0.05	Map3k6	Mitogen-activated protein kinase kinase	2.01	0.02
Lphn2	Latrophilin 2	−0.86	0.03	Fam107a	Family with sequence similarity 107, mem	2.00	0.03
Tfrc	Transferrin receptor	−0.82	0.02	Serpine1	Serine (or cysteine) peptidase inhibitor	1.72	0.01
Dusp18	Dual specificity phosphatase 18	−0.71	0.03	Zbtb16	Zinc finger and BTB domain containing 16	1.71	0.03
Slc26a10	Solute carrier family 26, member 10	−0.68	0.01	8430408G22Rik	RIKEN cDNA 8430408G22 gene	1.69	0.02
Slc6a6	Solute carrier family 6 (neurotransmitter transporter, taurine), member 6	−0.68	0.04	Ms4a4a	Membrane-spanning 4-domain, subfamily A	1.60	0.02
Kctd12b	Potassium channel tetramerisation domain	−0.66	0.03	Ctgf	Connective tissue growth factor	1.32	0.01
Cardiac myosin versus VP1u
Pdk4	Pyruvate dehydrogenase kinase, isoenzyme	−1.86	0.04	Igkc	Immunoglobulin kappa constant	2.54	0.03
Ces1d	Carboxylesterase 1D	−1.27	0.03	Trbj1-1	T cell receptor beta joining 1-1	1.73	0.04
Apln	Apelin	−0.96	0.05	Igj	Immunoglobulin joining chain	1.56	0.04
Ttn	Titin	−0.96	0.04	Comp	Cartilage oligomeric matrix protein	1.38	0.04
Klf15	Kruppel-like factor 15	−0.93	0.04	Mmp3	Matrix metallopeptidase 3	1.34	0.05
Ctnnal1	Catenin (cadherin associated protein), a	−0.93	0.01	Nox4	NADPH oxidase 4	1.07	0.04
Tacc2	Transforming Acidic Coiled-Coil Containing Protein 2	−0.84	0.02	Mcpt4	Mast cell protease 4	1.03	0.04
Scn4a	Sodium channel, voltage-gated, type IV	−0.82	0.03	Tfrc	Transferrin receptor	0.98	0.01
Gpam	Glycerol-3-phosphate acyltransferase, mi	−0.74	0.03	Rab2b	RAB2B, member RAS oncogene family	0.94	0.04
Cited2	Cbp/p300-interacting transactivator, wit	−0.73	0.04	Snord71	Small nucleolar RNA, C/D box 71	0.93	0.04
Fbxo32	F-box protein 32	−0.73145	0.04	Mgl2	Macrophage galactose N-acetyl-galactosamine specific lectin 2	0.91	0.01
Glul	Glutamate-ammonia ligase (glutamine synthase)	−0.68506	0.01	Glipr1	GLI pathogenesis-related 1 (glioma)	0.84	0.04