Review Article

Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis

Table 1

Causes of secondary FSGS.

TypeCause

Adaptive (with reduced renal mass)Oligomeganephronia, vesicoureteral reflux, low birth weight, unilateral renal agenesis, surgical renal ablation, chronic renal allograft nephropathy

Adaptive (with normal renal mass)Systemic hypertension, obesity, increased lean body mass, renal vasoocclusive disease, cyanotic congenital heart disease, sickle cell anemia

Drug-inducedHeroin, pamidronate, interferon, lithium, sirolimus

GeneticNPHS1, NPHS2, INF2, TRPC6, ACTN4, APOL1

Virus-associatedHIV-1, parvovirus B19, EBV, CMV