Phosphorylated and Nonphosphorylated PfMAP2 Are Localized in the Nucleus, Dependent on the Stage of Plasmodium falciparum Asexual Maturation

Figure 3

Schematic representation of the localization of phosphorylated PfMAP2. PPfMAP2 was shown to be in the nucleus. Expression of PPfMAP2 also extends into the cytosol in the areas surrounding the nucleus (P-TSH). NES-tagged PfMAP2 are thought to be transported from the cytosol to the nucleus. Upon phosphorylation, it will localize to the nucleus and activate downstream substrates.