Transcriptome Analysis of HepG2 Cells Expressing ORF3 from Swine Hepatitis E Virus to Determine the Effects of ORF3 on Host Cells

Figure 2

The DEGs obtained from H, E, and O cells by RNA-Seq. (a) The Venn diagrams indicated that the number of the significantly DEGs in O cells was 18. (b) Heat-maps indicated that, compared with that in H and E cells, in O cells, the mRNA levels of CLDN6, FREM1, SCARA3, FGG, FGA, FGB, APOC3, YLPMA1, and NLRP1 were upregulated, while KRT19, BPIFB2, SFN, ALCAM, SLC2A3, PTGR1, DKK1, S100A4, and NUPR1 were downregulated. Red indicates upregulation and green indicates downregulation.

(a)

(b)