The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis

Table 1

The current research related to miRNAs involved in osteoblast and osteoclast differentiation.

MicroRNA	Effect	Target	Reference
MiRNAs related to osteoblasts differentiation
MiR-210	Upregulate	VEGF	[77]
MiR-216a	Upregulate	Cb1-mediated PI3K/Akt	[82]
MiR-29a	Upregulate	Runx2	[68]
MiR-20a	Upregulate	BMP/Runx2	[59]
MiR-204	Downregulate	Runx2	[86]
MiR-705	Downregulate	HOXA10	[88]
MiR-3077-5p	Downregulate	Runx2	[88]
MiR-103a	Downregulate	Runx2	[17]
MiR-34c	Downregulate	BMP2	[101]
MiR-17-5p	Downregulate	BMP2	[102]
MiR-106a	Downregulate	BMP2	[102]
MiR-125b	Downregulate	Osterix	[91]
MiR-637	Downregulate	Osterix	[92]
MiR-188	Downregulate	Histone deacetylase 9 (HDAC9) and RPTOR-independent companion of MTOR complex 2 (RICTOR)	[93]
MiR-141-3p	Downregulate	Wnt signaling pathway	[94]
MiR-138	Downregulate	Focal adhesion kinase signaling pathway	[95]
MiR-338-3P	Downregulate	Runx2 and Fgfr2	[89, 90]
MiR-2861	Upregulate	HDAC5	[83]
MiR-378	Upregulate	Caspase-3	[103]
MiR-26a	Upregulate	SMAD1	[104]
MiRNAs related to osteoclasts differentiation
MiR-503	Downregulate	RANKL	[97]
MiR-148a	Upregulate	RANKL	[98]
MiR-34a	Downregulate	TGFβ-2	[105]
MiR-214	Upregulate	PI3K/Akt	[106]
MiR-17	Downregulate	RANKL	[60]
MiR-20a	Downregulate	RANKL	[60]
MiR-26a	Downregulate	CTGF	[107]