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BioMed Research International
Volume 2016, Article ID 1784161, 7 pages
http://dx.doi.org/10.1155/2016/1784161
Research Article

Oxymatrine Inhibits Proliferation and Migration While Inducing Apoptosis in Human Glioblastoma Cells

Department of Pediatric Neurosurgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China

Received 8 April 2016; Accepted 2 August 2016

Academic Editor: Jialiang Yang

Copyright © 2016 Feili Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Q. T. Ostrom, H. Gittleman, P. Liao et al., “CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007–2011,” Neuro-Oncology, vol. 16, supplement 5, pp. iv1–iv63, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Stupp, W. P. Mason, M. J. van den Bent et al., “Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma,” The New England Journal of Medicine, vol. 352, no. 10, pp. 987–996, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Stupp, M. E. Hegi, W. P. Mason et al., “Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial,” The Lancet Oncology, vol. 10, no. 5, pp. 459–466, 2009. View at Publisher · View at Google Scholar
  4. D. R. Johnson and B. P. O'Neill, “Glioblastoma survival in the United States before and during the temozolomide era,” Journal of Neuro-Oncology, vol. 107, no. 2, pp. 359–364, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. I. Paw, R. C. Carpenter, K. Watabe, W. Debinski, and H.-W. Lo, “Mechanisms regulating glioma invasion,” Cancer Letters, vol. 362, no. 1, pp. 1–7, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. S.-P. Weathers and J. de Groot, “VEGF manipulation in glioblastoma,” Oncology, vol. 29, no. 10, pp. 720–727, 2015. View at Google Scholar · View at Scopus
  7. Y.-P. Wang, F. Liu, H.-W. He et al., “Heat stress cognate 70 host protein as a potential drug target against drug resistance in hepatitis B virus,” Antimicrobial Agents and Chemotherapy, vol. 54, no. 5, pp. 2070–2077, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. N.-L. Chai, Q. Fu, H. Shi et al., “Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells,” World Journal of Gastroenterology, vol. 18, no. 31, pp. 4199–4206, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. J. R. Guzman, J. S. Koo, J. R. Goldsmith, M. Mühlbauer, A. Narula, and C. Jobin, “Oxymatrine prevents NF-κB nuclear translocation and ameliorates acute intestinal inflammation,” Scientific Reports, vol. 3, article 1629, pp. 1–9, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Yong-Gang, J. Shan, L. Lei et al., “Antiarrhythmic effects and ionic mechanisms of oxymatrine from Sophora flavescens,” Phytotherapy Research, vol. 24, no. 12, pp. 1844–1849, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. Q. Ling, X. Xu, X. Wei et al., “Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c,” Journal of Experimental and Clinical Cancer Research, vol. 30, no. 1, article 66, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Wang, Q. Han, Y. Zhu et al., “Oxymatrine inhibited cell proliferation by inducing apoptosis in human lung cancer A549 cells,” Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S165–S172, 2015. View at Publisher · View at Google Scholar
  13. B. Guo, T. Zhang, J. Su, K. Wang, and X. Li, “Oxymatrine targets EGFRp-Tyr845 and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells,” Cancer Chemotherapy and Pharmacology, vol. 75, no. 2, pp. 353–363, 2015. View at Publisher · View at Google Scholar
  14. Y. Zhang, B. Piao, Y. Zhang et al., “Oxymatrine diminishes the side population and inhibits the expression of β-catenin in MCF-7 breast cancer cells,” Medical Oncology, vol. 28, supplement 1, pp. S99–S107, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Liu, Y. Xu, W. Ji et al., “Anti-tumor activities of matrine and oxymatrine: literature review,” Tumor Biology, vol. 35, no. 6, pp. 5111–5119, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Zhang, J. Qi, L. Sun et al., “Matrine induces programmed cell death and regulates expression of relevant genes based on PCR array analysis in C6 glioma cells,” Molecular Biology Reports, vol. 36, no. 4, pp. 791–799, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Zheng, C. Li, X. Shan, H. Liu, W. Fan, and Z. Wang, “A study on isolation of chemical constituents from Sophora flavescens Ait. and their anti-glioma effects,” African Journal of Traditional, Complementary, and Alternative Medicines, vol. 11, no. 1, pp. 156–160, 2014. View at Google Scholar · View at Scopus
  18. J. Liu, Y. Yao, H. Ding, and R. Chen, “Oxymatrine triggers apoptosis by regulating Bcl-2 family proteins and activating caspase-3/caspase-9 pathway in human leukemia HL-60 cells,” Tumor Biology, vol. 35, no. 6, pp. 5409–5415, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. I. M. Ghobrial, T. E. Witzig, and A. A. Adjei, “Targeting apoptosis pathways in cancer therapy,” CA: A Cancer Journal for Clinicians, vol. 55, no. 3, pp. 178–194, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Chou, M. Chang, M. Wang, and T. Harnod, “PEITC induces apoptosis of Human Brain Glioblastoma GBM8401 cells through the extrinsic- and intrinsic -signaling pathways,” Neurochemistry International, vol. 81, pp. 32–40, 2015. View at Publisher · View at Google Scholar
  21. Z. Jin and W. S. El-Deiry, “Overview of cell death signaling pathways,” Cancer Biology & Therapy, vol. 4, no. 2, pp. 139–163, 2005. View at Google Scholar · View at Scopus
  22. T. Tsuruo, M. Naito, A. Tomida et al., “Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal,” Cancer Science, vol. 94, no. 1, pp. 15–21, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Jin, J. Hu, Q. Wang, Z. Li, and Y. Chen, “Effects of Oxymatrine on the apoptosis of human esophageal carcinoma Eca109 cell line and its mechanism,” Journal of Huazhong University of Science and Technology (Medical Sciences), vol. 28, no. 3, pp. 314–316, 2008. View at Google Scholar
  24. J. Wei, Y. Zhu, G. Xu et al., “Oxymatrine extracted from sophora flavescens inhibited cell growth and induced apoptosis in human osteosarcoma MG-63 cells in vitro,” Cell Biochemistry and Biophysics, vol. 70, no. 2, pp. 1439–1444, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. G. Song, Q. Luo, J. Qin, L. Wang, Y. Shi, and C. Sun, “Effects of oxymatrine on proliferation and apoptosis in human hepatoma cells,” Colloids and Surfaces B: Biointerfaces, vol. 48, no. 1, pp. 1–5, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Zhang, S. Sun, J. Chen et al., “Oxymatrine induces mitochondria dependent apoptosis in human osteosarcoma MNNG/HOS cells through inhibition of PI3K/Akt pathway,” Tumor Biology, vol. 35, no. 2, pp. 1619–1625, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. T. F. Cloughesy, W. K. Cavenee, and P. S. Mischel, “Glioblastoma: from molecular pathology to targeted treatment,” Annual Review of Pathology: Mechanisms of Disease, vol. 9, pp. 1–25, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Vehlow and N. Cordes, “Invasion as target for therapy of glioblastoma multiforme,” Biochimica et Biophysica Acta (BBA)—Reviews on Cancer, vol. 1836, no. 2, pp. 236–244, 2013. View at Publisher · View at Google Scholar · View at Scopus