Mitochondria Biogenesis and Bioenergetics Gene Profiles in Isogenic Prostate Cells with Different Malignant Phenotypes

Table 1

Differentially expressed mitochondria associated genes in RC77T/E versus RC77N/E.

Gene ID	Gene	Fold change	value	Mitochondrial function
ATP5F1	ATP synthase F(0) complex subunit B1	2.335	0.003692	Complex V (ATP synthase)
ATP5G1	ATP synthase F(0) complex subunit C1	3.29	0.000036	Complex V (ATP synthase)
ATP5G3	ATP synthase F(0) complex subunit C3	2.3634	0.000079	Complex V (ATP synthase)
ATP5L	ATP synthase, mitochondrial F0 complex, subunit E	3.7348	0.000572	Complex V (ATP synthase)
BAK1	BCL2-antagonist/killer 1	5.4275	0.001285	Apoptosis, membrane polarization and potential
BCL2L1	BCL2-like 1	2.5872	0.000284	Apoptosis, membrane polarization and potential
BID	BH3 interacting domain death agonist	2.1975	0.000056	Apoptosis, membrane polarization and potential
CDKN2A	Cyclin-dependent kinase inhibitor 2A	3.863	0.000005	Apoptosis
CPT2	Carnitine palmitoyltransferase 2	2.2704	0.007064	Mitochondrial transport, import of palmitoyl-CoA
DNM1L	Dynamin 1-like	3.3432	0.000016	Apoptosis, mitochondrial localization
GRPEL1	GrpE-like 1, mitochondrial	3.1984	0.000099	Targeting proteins to mitochondria, protein import
HSP90AA1	Heat shock protein 90 kDa alpha (cytosolic), class A member 1	3.7062	0.000006	Mitochondrial transport, molecular chaperone
HSPA1A	Heat shock 70 kDa protein 1A	2.478	0.000413	Molecular chaperone
HSPA1B	Heat shock 70 kDa protein 1B	2.405	0.031481	Molecular chaperone
HSPD1	Heat shock 60 kDa protein 1 (chaperonin)	2.1902	0.000003	Mitochondrial transport, mitochondria chaperone
MSTO1	Misato homolog 1	2.3655	0.000371	Mitochondrial localization, distribution and morphology
NDUFA8	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	2.864	0.000012	Complex I (NADH-coenzyme Q reductase)
NDUFB6	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	3.705	0.000014	Complex I (NADH-coenzyme Q reductase)
NDUFC1	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	4.3791	0.000068	Complex I (NADH-coenzyme Q reductase)
NDUFS5	NADH dehydrogenase (ubiquinone) Fe-S protein 5	2.0443	0.000034	Complex I (NADH-coenzyme Q reductase)
NDUFS7	NADH dehydrogenase (ubiquinone) Fe-S protein 7	2.1198	0.057441	Complex I (NADH-coenzyme Q reductase)
NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2	3.5214	0.000063	Complex I (NADH-coenzyme Q reductase)
NEFL	Neurofilament, light polypeptide	−4.3762	0.000097	Mitochondrial localization, potential tumor suppressor
RHOT2	Ras homolog gene family, member T2	2.0615	0.000081	Mitochondrial localization, mitochondrial trafficking
SLC25A13	Solute carrier family 25, member 13 (citrin)	3.7679	0.000022	Small molecule transport, aspartate glutamate carrier
SLC25A19	Solute carrier family 25 (thiamine pyrophosphate carrier), member 19	2.4244	0.000124	Small molecule transport, thiamine pyrophosphate carrier
SLC25A20	Solute carrier family 25 (carnitine/acylcarnitine), member 20	3.5411	0.00002	Small molecule transport, transport of acylcarnitines
SLC25A22	Solute carrier family 25 (glutamate carrier), member 22	3.1844	0.000272	Small molecule transport, glutamate/H(+) symporter 1
SLC25A25	Solute carrier family 25 (phosphate carrier), member 25	3.2177	0.000105	Calcium-dependent mitochondrial solute carrier
SLC25A25	Solute carrier family 25 (phosphate carrier), member 25	2.3477	0.000454	Calcium-dependent mitochondrial solute carrier
SLC25A3	Solute carrier family 25 (phosphate carrier), member 3	2.1644	0.000049	Small molecule transport, phosphate transport
SLC25A37	Solute carrier family 25, member 37	2.7408	0.000096	Small molecule transport, mitochondrial iron transporter
SOD1	Superoxide dismutase 1	2.5797	0.000002	Membrane polarization and potential, detoxification of ROS
SOD2	Superoxide dismutase 2, mitochondrial	2.4298	0.000013	Apoptosis, destruction of superoxide anion radicals
TIMM10B	Mitochondrial import inner membrane translocase subunit	2.384	0.000082	Protein import, inner membrane translocation
TIMM17A	Translocase of inner mitochondrial membrane 17A	2.3979	0.00002	Inner membrane translocation
TIMM17B	Translocase of inner mitochondrial membrane 17B	2.1244	0.000009	Inner membrane translocation
TIMM22	Translocase of inner mitochondrial membrane 22	2.9497	0.000287	Inner membrane translocation
TIMM23	Translocase of inner mitochondrial membrane 23	2.276	0.000005	Inner membrane translocation
TIMM50	Translocase of inner mitochondrial membrane 50	2.4393	0.000534	Inner membrane translocation
TIMM8B	Translocase of inner mitochondrial membrane 8B	2.2896	0.000022	Inner membrane translocation
TOMM22	Translocase of outer mitochondrial membrane 22	2.4539	0.000001	Mitochondrial import receptor
TOMM34	Translocase of outer mitochondrial membrane 34	3.579	0.000006	Outer membrane translocation
TOMM40	Translocase of outer mitochondrial membrane 40	3.0187	0.000026	Outer membrane translocation
TOMM40L	Translocase of outer mitochondrial membrane 40-like	4.1483	0.000108	Outer membrane translocation
TP53	Tumor protein p53	2.0973	0.000006	Tumor suppressor
UCP2	Uncoupling protein 2	10.5781	0	Transport, uncoupling oxidative phosphorylation
UQCRQ	Cytochrome b-c1 complex subunit 8	2.2169	0.000029	Complex III (coenzyme Q-cytochrome c reductase)