| | Symbol | Description | T2DM | Prediabetes | | Fold changes | 95% CI | Fold changes | 95% CI |
| | ACE | Angiotensin I converting enzyme | 1.69 | (0.95, 2.43) | — | — | | ADAM17 | ADAM metallopeptidase domain 17 | 1.788 | (0.00001, 3.93) | 1.5804 | (1.01, 2.15) | | AGT | Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | — | — | 1.8188 | (1.16, 2.47) | | ALOX5 | Arachidonate 5-lipoxygenase | 3.6158 | (1.93, 5.30) | 2.1048 | (1.33, 2.88) | | ANGPT1 | Angiopoietin 1 | 2.3495 | (1.29, 3.41) | — | — | | ANXA5 | Annexin A5 | 2.5639 | (1.79, 3.34) | 1.8502 | (1.16, 2.54) | | APOE | Apolipoprotein E | 3.2588 | (1.76, 4.76) | — | — | | BAX | BCL2-associated X protein | 2.5497 | (1.69, 3.41) | 1.883 | (1.21, 2.56) | | BCL2 | B-cell CLL/lymphoma 2 | 2.0567 | (1.29, 2.82) | 1.6294 | (1.03, 2.23) | | BCL2L1 | BCL2-like 1 | 1.8493 | (0.67, 3.03) | — | — | | CALCA | Calcitonin-related polypeptide alpha | 2.6938 | (1.51, 3.88) | 1.8562 | (1.17, 2.55) | | CASP1 | Caspase 1, apoptosis-related cysteine peptidase | 2.3823 | (1.62, 3.14) | 2.2207 | (1.41, 3.04) | | CASP3 | Caspase 3, apoptosis-related cysteine peptidase | 2.9032 | (0.00001, 6.08) | 2.8474 | (0.00001, 5.98) | | CCL2 | Chemokine (C-C motif) ligand 2 | 1.7255 | (0.68, 2.77) | — | — | | CCL5 | Chemokine (C-C motif) ligand 5 | 0.6962 | (0.52, 0.87) | — | — | | CDH5 | Cadherin 5, type 2 (vascular endothelium) | 3.4734 | (1.53, 5.42) | — | — | | CFLAR | CASP8 and FADD-like apoptosis regulator | 2.3999 | (1.33, 3.47) | 1.5695 | (0.74, 2.40) | | COL18A1 | Collagen, type XVIII, alpha 1 | 2.4144 | (0.85, 3.98) | 2.171 | (1.13, 3.21) | | CX3CL1 | Chemokine (C-X3-C motif) ligand 1 | 4.2901 | (2.08, 6.50) | 2.816 | (1.23, 4.41) | | EDN1 | Endothelin 1 | 1.8622 | (1.11, 2.62) | 1.5294 | (0.78, 2.28) | | EDN2 | Endothelin 2 | 2.456 | (0.41, 4.50) | 1.3964 | (0.96, 1.84) | | EDNRA | Endothelin receptor type A | 1.9702 | (0.81, 3.13) | — | | | ENG | Endoglin | — | — | 1.9575 | (1.25, 2.66) | | F2R | Coagulation factor II (thrombin) receptor | — | — | 2.1302 | (1.16, 3.10) | | F3 | Coagulation factor III (thromboplastin, tissue factor) | 2.7747 | (1.53, 4.02) | 1.9368 | (0.94, 2.93) | | FAS | Fas (TNF receptor superfamily, member 6) | 2.4166 | (1.17, 3.66) | — | — | | FASLG | Fas ligand (TNF superfamily, member 6) | — | — | 1.6629 | (1.03, 2.30) | | FGF1 | Fibroblast growth factor 1 (acidic) | 0.7285 | (0.59, 0.87) | — | — | | FLT1 | Fms-related tyrosine kinase 1 | 2.177 | (1.54, 2.81) | 1.4185 | (0.99, 1.84) | | FN1 | Fibronectin 1 | 48.4245 | (0.00001, 105.64) | 3.0987 | (1.00, 5.20) | | ICAM1 | Intercellular adhesion molecule 1 | — | — | 1.8786 | (1.17, 2.58) | | IL11 | Interleukin 11 | 2.1411 | (1.31, 2.97) | — | — | | IL1B | Interleukin 1, beta | 2.9739 | (1.87, 4.08) | 1.8899 | (1.24, 2.54) | | IL3 | Interleukin 3 (colony-stimulating factor, multiple) | 176.599 | (0.00001, 474.01) | 2.4413 | (1.44, 3.44) | | IL6 | Interleukin 6 (interferon, beta 2) | 1.6806 | (0.97, 2.39) | — | — | | IL7 | Interleukin 7 | 1.3835 | (0.71, 2.06) | — | — | | ITGA5 | Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 2.6864 | (1.61, 3.76) | 1.8891 | (1.19, 2.59) | | ITGAV | Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 1.7913 | (1.17, 2.41) | 1.6077 | (1.00, 2.21) | | ITGB1 | Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 including MDF2, MSK12) | 1.9693 | (1.44, 2.49) | 1.6144 | (0.98, 2.24) | | ITGB3 | Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 4.9899 | (2.90, 7.08) | 2.5427 | (0.65, 4.43) | | KDR | Kinase insert domain receptor (a type III receptor tyrosine kinase) | 1.6884 | (0.78, 2.59) | — | — | | KIT | V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 1.6025 | (0.89, 2.31) | 1.6211 | (1.07, 2.18) | | MMP1 | Matrix metallopeptidase 1 | 12.8082 | (3.18, 22.43) | | | | MMP2 | Matrix metallopeptidase 2 | 2.6715 | (0.87, 4.47) | 1.7691 | (1.13, 2.41) | | MMP9 | Matrix metallopeptidase 9 | 4.4005 | (2.21, 6.60) | — | — | | NOS3 | Nitric oxide synthase 3 (endothelial cell) | 2.5532 | (1.62, 3.48) | — | — | | PECAM1 | Platelet/endothelial cell adhesion molecule | 0.5887 | (0.35, 0.82) | 0.2377 | (0.14, 0.33) | | PF4 | Platelet factor 4 | — | — | 1.397 | (0.62, 2.17) | | PGF | Placental growth factor | 2.9547 | (1.87, 4.04) | 2.2258 | (1.21, 3.24) | | PLAT | Plasminogen activator, tissue | 1.788 | (1.03, 2.55) | 2.0088 | (1.03, 2.99) | | PLAU | Plasminogen activator, urokinase | 7.8263 | (2.73, 12.93) | 3.6782 | (1.53, 5.83) | | PLG | Plasminogen | 3.8718 | (1.36, 6.38) | 2.18 | (0.52, 3.84) | | PROCR | Protein C receptor, endothelial | — | — | 1.7096 | (1.08, 2.34) | | PTGIS | Prostaglandin I2 (prostacyclin) synthase | — | — | 2.18 | (1.22, 3.14) | | PTGS2 | Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 2.5639 | (1.08, 4.05) | 2.0312 | (1.25, 2.81) | | PTK2 | PTK2 protein tyrosine kinase 2 | 1.7263 | (0.84, 2.62) | — | — | | SELE | Selectin E | 1.8021 | (0.90, 2.70) | 2.3075 | (1.17, 3.44) | | SELL | Selectin L | 2.4044 | (1.58, 3.22) | 1.6476 | (1.16, 2.13) | | SELPLG | Selectin P ligand | 2.42 | (1.80, 3.04) | 2.0023 | (1.37, 2.64) | | SERPINE1 | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 3.2035 | (1.87, 4.53) | 2.0463 | (1.12, 2.97) | | SOD1 | Superoxide dismutase 1, soluble | 0.6517 | (0.46, 0.84) | 0.5267 | (0.33, 0.73) | | SPHK1 | Sphingosine kinase 1 | 2.2258 | (1.35, 3.10) | 1.6339 | (0.65, 2.62) | | TEK | TEK tyrosine kinase, endothelial | — | — | 2.2454 | (1.29, 3.20) | | TFPI | Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 1.4959 | (0.95, 2.04) | — | — | | TGFB1 | Transforming growth factor, beta 1 | 2.8056 | (1.88, 3.73) | 3.142 | (1.70, 4.58) | | THBD | Thrombomodulin | 3.685 | (2.00, 5.37) | 2.0097 | (1.20, 2.82) | | THBS1 | Thrombospondin 1 | 1.8588 | (1.18, 2.54) | 1.433 | (0.75, 2.12) | | TIMP1 | TIMP metallopeptidase inhibitor 1 | 2.6814 | (1.82, 3.54) | 3.283 | (1.82, 4.74) | | TNF | Tumor necrosis factor | 1.5922 | (1.11, 2.07) | — | — | | TNFSF10 | Tumor necrosis factor (ligand) superfamily, member 10 | 1.5084 | (1.07, 1.94) | — | — | | TYMP | Thymidine phosphorylase | — | — | 2.9739 | (1.01, 4.93) | | VEGFA | Vascular endothelial growth factor A | 2.0406 | (1.44, 2.64) | — | — | | VWF | Von Willebrand factor | 2.035 | (1.41, 2.66) | 1.6226 | (0.92, 2.32) |
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