BioMed Research International / 2016 / Article / Tab 2

Review Article

Applications of Chondrocyte-Based Cartilage Engineering: An Overview

Table 2

Differences of autologous transplantation/implantation generations.

First generationSecond generationThird generation

DescriptionAutologous chondrocyte suspension with periosteumAutologous chondrocyte suspension with collagen membraneAutologous chondrocyte suspension in biomaterials

Cells source/delivery
procedure
Carticel, periosteum patch
ChondroCelect, characterized chondrocyte implantation
(expanded population of chondrocytes that expresses a marker profile predictive of the capacity to form stable hyaline-like cartilage in vivo)
Chondro-Gide
Bilayer
membrane
MACI®, CaReS®, Tissucol®, NeoCart
type I/III collagen, fibrin glue,
type I/III collagen bilayer, BioSeed® C,
esterified derivative of hyaluronate
Hyalograft® C, fibrin glue + 
polymer-based scaffold of polyglycolic/polylactic acid and polydioxanone
collagen type I gel seeded with autologous
chondrocyte directly after isolation

Adopted from Samsudin and Kamarul, 2015 [101].

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