BioMed Research International / 2016 / Article / Tab 2

Review Article

Applications of Chondrocyte-Based Cartilage Engineering: An Overview

Table 2

Differences of autologous transplantation/implantation generations.

First generationSecond generationThird generation

DescriptionAutologous chondrocyte suspension with periosteumAutologous chondrocyte suspension with collagen membraneAutologous chondrocyte suspension in biomaterials

Cells source/delivery
Carticel, periosteum patch
ChondroCelect, characterized chondrocyte implantation
(expanded population of chondrocytes that expresses a marker profile predictive of the capacity to form stable hyaline-like cartilage in vivo)
MACI®, CaReS®, Tissucol®, NeoCart
type I/III collagen, fibrin glue,
type I/III collagen bilayer, BioSeed® C,
esterified derivative of hyaluronate
Hyalograft® C, fibrin glue + 
polymer-based scaffold of polyglycolic/polylactic acid and polydioxanone
collagen type I gel seeded with autologous
chondrocyte directly after isolation

Adopted from Samsudin and Kamarul, 2015 [101].

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.