Gender-Specific Association of ATP2B1 Variants with Susceptibility to Essential Hypertension in the Han Chinese Population

Table 2

Association statistics for the ATP2B1 variants and hypertension.

SNP	Genotype	Group	Genotype			MAF	P value	OR	95% CI
rs3741895	AA/AG/GG	Case	778	122	0	0.07	0.954	0.99	0.77–1.29
		Control	778	121	0	0.07
		Male case	331	58	0	0.07	0.433	0.86	0.58–1.27
		Male control	338	50	0	0.06
		Female case	447	64	0	0.06	0.533	1.12	0.79–1.59
		Female control	440	71	0	0.07
rs2854371	CC/CT/TT	Case	519	339	44	0.24	0.879	1.01	0.87–1.18
		Control	510	347	41	0.24
		Male case	226	143	21	0.24	0.648	0.95	0.75–1.20
		Male control	226	146	15	0.23
		Female case	293	196	23	0.24	0.553	1.06	0.87–1.30
		Female control	284	201	26	0.25
rs2070759	AA/AC/CC	Case	266	453	183	0.45	0.036	1.15	1.01–1.31
		Control	223	476	203	0.49
		Male case	107	201	82	0.47	0.879	1.02	0.83–1.24
		Male control	109	194	87	0.47
		Female case	159	252	101	0.44	0.008	1.27	1.06–1.51
		Female control	114	282	116	0.50
rs11105357	CC/CT/TT	Case	722	172	8	0.10	0.472	0.92	0.74–1.15
		Control	733	163	6	0.10
		Male case	320	64	6	0.10	0.407	1.15	0.83–1.59
		Male control	309	76	5	0.11
		Female case	402	108	2	0.11	0.088	0.78	0.58–1.04
		Female control	424	87	1	0.09
rs957525	AA/AG/GG	Case	546	314	40	0.22	0.705	1.03	0.88–1.21
		Control	541	313	45	0.22
		Male case	245	132	12	0.20	0.239	1.16	0.91–1.48
		Male control	231	141	17	0.22
		Female case	301	182	28	0.23	0.615	0.95	0.77–1.17
		Female control	310	172	28	0.22
rs11105358	CC/CG/GG	Case	43	311	547	0.22	0.160	1.12	0.96–1.32
		Control	35	293	574	0.20
		Male case	24	124	242	0.22	0.903	1.02	0.80–1.29
		Male control	18	134	238	0.22
		Female case	19	187	305	0.22	0.076	1.22	0.98–1.51
		Female control	17	159	336	0.19
rs17249754	AA/AG/GG	Case	102	417	383	0.34	0.005	0.82	0.72–0.94
		Control	143	416	343	0.39
		Male case	46	182	162	0.35	0.128	0.85	0.69–1.05
		Male control	59	185	146	0.39
		Female case	56	235	221	0.34	0.017	0.80	0.67–0.96
		Female control	84	231	197	0.39

P values were obtained from the comparison of two allele frequencies. OR: odds ratio; CI: confidence interval. P value was less than 0.05.