Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells

Figure 1

In vivo monitoring of macrophage migration toward inflammatory lesions by using optical imaging modality. (a) The right hind limb of Balb/c mice was intramuscularly injected with turpentine oil to induce inflammation. Seven days later, Raw264.7 cells expressing the enhanced firefly luciferase (effluc) gene were intravenously administered to these mice. Bioluminescence imaging was undertaken at days 1, 3, 5, and 7 after injection of Raw264.7/effluc cells. (b) The bioluminescence signals from Raw264.7 cells were used to quantify the migration of cells toward the inflammatory lesion. Data are expressed as the mean ± SD.

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