Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways

Figure 1

Protection effect of tropisetron in APAP-induced liver injury. Mice were intraperitoneally administered with APAP 300 mg/kg alone or with various concentrations of tropisetron (TP: 0.3 to 10 mg/kg) at 30 min before APAP injection and were sacrificed 20 h after administration for assay of sera ALT (a) and AST (b). Results are mean ± SEM; = 6 mice per group. versus control (normal saline); ; versus APAP alone.

(a)

(b)