Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways

Figure 3

Tropisetron protects against APAP-induced hepatic GSH, SOD depletion, and MDA increase. Mice were administered with APAP 300 mg/kg alone or with tropisetron (TP: 1 and 3 mg/kg) at 30 min before APAP injection and were sacrificed 20 h after administration for assay of liver GSH (a), SOD (b), and MDA (c). Results are mean ± SEM; = 6 mice per group. versus control (normal saline); ; ; versus APAP alone.

(a)

(b)

(c)