Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways

Figure 4

Tropisetron reduces APAP-induced liver injury in histology. Mice were given (a) control (normal saline) and (b) APAP 300 mg/kg alone or with various concentrations of tropisetron ((c) 1 mg/kg; (d) 3 mg/kg; (e) 10 mg/kg) at 30 min before APAP injection and were sacrificed 20 h after administration for assay by H&E stain (magnification: left column ×50, right column ×100).