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BioMed Research International
Volume 2016, Article ID 1952947, 9 pages
Research Article

Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways

Department of Anesthesiology, Linkou Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan 33305, Taiwan

Received 1 July 2016; Revised 9 September 2016; Accepted 3 October 2016

Academic Editor: Udayan Apte

Copyright © 2016 Fu-Chao Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

To evaluate the effect of tropisetron in mice treated early after APAP overdose, we compared the pretreatment and posttreatment effect of tropisetron in APAP-induced liver. The results showed that pre- or posttreatment with tropisetron (3 mg/kg) has similar effects in reducing APAP-induced liver injury. However, there is no statistical difference between pretreated and posttreated groups with tropisetron (3 mg/kg).

  1. Supplementary Material