Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016 (2016), Article ID 1957374, 7 pages
http://dx.doi.org/10.1155/2016/1957374
Research Article

The Association between NOS3 Gene Polymorphisms and Hypoxic-Ischemic Encephalopathy Susceptibility and Symptoms in Chinese Han Population

1Department of Nursing, Xinxiang Central Hospital, Affiliated Central Hospital, Xinxiang Medical University, No. 56, Jinsui Road, Xinxiang 453000, China
2Department of Pediatrics, Xinxiang Central Hospital, Affiliated Central Hospital, Xinxiang Medical University, No. 56, Jinsui Road, Xinxiang 453000, China
3Department of Pediatric Rehabilitation, Xinxiang Central Hospital, Affiliated Central Hospital, Xinxiang Medical University, No. 56, Jinsui Road, Xinxiang 453000, China

Received 18 August 2016; Revised 9 November 2016; Accepted 27 November 2016

Academic Editor: Cristiano Capurso

Copyright © 2016 Yongqin Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Endothelial NOS (NOS3) has a potential role in the prevention of neuronal injury in hypoxic-ischemic encephalopathy (HIE). Thus, we aimed to explore the association between NOS3 gene polymorphisms and HIE susceptibility and symptoms in a Chinese Han population. Three single nucleotide polymorphisms (SNPs) in the NOS3 gene, rs1800783, rs1800779, and rs2070744, were detected in 226 children with HIE and 212 healthy children in a Chinese Han population. Apgar scores and magnetic resonance image scans were used to estimate the symptoms and brain damage. The association analyses were conducted by using SNPStats and SPSS 18.0 software. The genotype and allele distributions of rs1800779 and rs1799983 displayed no significant differences between the patients and the controls, while the rs2070744 allele distribution was significantly different (corrected ). For clinical characteristics, the rs2070744 genotype distribution was significantly different in patients with different Apgar scores (≤5, TT/TC/CC = 6/7/5; 6~7, TT/TC/CC = 17/0/0; 8~9, TT/TC/CC = 6/2/0; 10, TT/TC/CC = 7/1/0; corrected ) in the 1001 to 1449 g birth weight subgroup. The haplotype test did not show any associations with the risk and clinical characteristics of HIE. The results suggest that NOS3 gene SNP rs2070744 was significantly associated with HIE susceptibility and symptom expression in Chinese Han population.