Improved Stability of a Model IgG3 by DoE-Based Evaluation of Buffer Formulations

<div>Significant interations on HR stability after both<i> T</i>30 (a) and freeze/thaw (b), and interactions between two variables lead to to significantly decreased<i> A</i>410. At<i> T</i>30 (a), NaCl concentration in combination with pH leads to a more desireable<i> A</i>410. After F/T (b), the interaction between arginine and histidine concentrations had a significant effect on<i> A</i>410<i>.</i></div>

BioMed Research International

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Figure 4

Figure 4: Improved Stability of a Model IgG3 by DoE-Based Evaluation of Buffer Formulations 